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Abnormal Brain MRI Signals in the Splenium of the Corpus Callosum, Basal Ganglia and Internal Capsule in a Suspected Case with Tuberculous Meningitis

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Title: Abnormal Brain MRI Signals in the Splenium of the Corpus Callosum, Basal Ganglia and Internal Capsule in a Suspected Case with Tuberculous Meningitis
Authors: Hirotani, Makoto Browse this author →KAKEN DB
Yabe, Ichiro Browse this author →KAKEN DB
Hamada, Shinsuke Browse this author
Tsuji, Sachiko Browse this author
Kikuchi, Seiji Browse this author
Sasaki, Hidenao Browse this author →KAKEN DB
Keywords: tuberculous meningitis
basal ganglia
splenium of the corpus callosum
Internal capsule
allergic tuberculous encephalopathy
Issue Date: 17-Apr-2007
Publisher: Japanese Society of Internal Medicine
Journal Title: Internal Medicine
Volume: 46
Issue: 8
Start Page: 505
End Page: 510
Publisher DOI: 10.2169/internalmedicine.46.6168
Abstract: The patient was a 34-year-old man who visited the hospital with chief complaints of headache, fever, and disturbance of consciousness. In view of his clinical condition, the course of the disease, and results of examination, he was diagnosed with viral meningitis and treated accordingly. However, his clinical condition worsened, and MRI revealed abnormal signals in the splenium of the corpus callosum, in the basal ganglia and in the internal capsule, as well as the presence of severe inflammation in the base of the brain. Since he had a high ADA level in the cerebrospinal fluid and was consequently suspected to have tuberculous meningitis, he was placed on antitubercular agents. Then, his clinical condition began to improve. Additional steroid pulse therapy further improved his condition, and abnormal signals in the splenium of the corpus callosum and the basal ganglia resolved. This patient seems to be a valuable case suggesting that an immune mechanism contributed to the occurrence of central nervous system symptoms associated with tuberculous meningitis.
Type: article (author version)
URI: http://hdl.handle.net/2115/20466
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 矢部 一郎

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