Title: | Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist |
Authors: | Miseki, T. Browse this author |
Kawakami, H. Browse this author |
Natsuizaka, M. Browse this author |
Darmanin, S. Browse this author |
Cui, H. Y. Browse this author |
Chen, J. Browse this author |
Fu, Q. Browse this author |
Okada, F. Browse this author |
Shindo, M. Browse this author |
Higashino, F. Browse this author |
Asaka, M. Browse this author →KAKEN DB |
Hamuro, J. Browse this author |
Kobayashi, M. Browse this author |
Keywords: | hypoxia |
glucose deprivation |
adrenomedullin |
adrenomedullin antagonist |
naked DNA |
Issue Date: | Jan-2007 |
Publisher: | Nature Publishing Group |
Journal Title: | Cancer Gene Therapy |
Volume: | 14 |
Issue: | 1 |
Start Page: | 39 |
End Page: | 44 |
Publisher DOI: | 10.1038/sj.cgt.7700979 |
PMID: | 16841081 |
Abstract: | We have recently reported that the intra-tumoral injection of adrenomedullin (AM) antagonist (AMA; AM (22-52)) peptides significantly reduced the in vivo growth of a pancreatic cancer cell line in severely combined immunodeficient (SCID) mice. In the present study, we examined the effects of intra-tumoral and intra-muscular transfers of naked DNA encoding AMA on the in vivo growth of cancer cell lines. We demonstrate that these treatments induce the regression of a pancreatic cancer cell line and a breast cancer cell line inoculated in SCID mice. Furthermore, CD31-positive cells disappear completely from tumor tissues, following treatment, indicating that neo-vascularization is entirely inhibited. These results suggest that the intra-tumoral or intra-muscular transfer of naked DNA encoding AMA might be a promising alternative modality for treating human cancers. |
Rights: | Nature Publishing Group, Cancer Gene Therapy, Vol.14-1, 2007, pp. 39-44 |
Relation: | http://www.nature.com/npg/ |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/25155 |
Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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