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Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist

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Title: Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist
Authors: Miseki, T. Browse this author
Kawakami, H. Browse this author
Natsuizaka, M. Browse this author
Darmanin, S. Browse this author
Cui, H. Y. Browse this author
Chen, J. Browse this author
Fu, Q. Browse this author
Okada, F. Browse this author
Shindo, M. Browse this author
Higashino, F. Browse this author
Asaka, M. Browse this author →KAKEN DB
Hamuro, J. Browse this author
Kobayashi, M. Browse this author
Keywords: hypoxia
glucose deprivation
adrenomedullin
adrenomedullin antagonist
naked DNA
Issue Date: Jan-2007
Publisher: Nature Publishing Group
Journal Title: Cancer Gene Therapy
Volume: 14
Issue: 1
Start Page: 39
End Page: 44
Publisher DOI: 10.1038/sj.cgt.7700979
PMID: 16841081
Abstract: We have recently reported that the intra-tumoral injection of adrenomedullin (AM) antagonist (AMA; AM (22-52)) peptides significantly reduced the in vivo growth of a pancreatic cancer cell line in severely combined immunodeficient (SCID) mice. In the present study, we examined the effects of intra-tumoral and intra-muscular transfers of naked DNA encoding AMA on the in vivo growth of cancer cell lines. We demonstrate that these treatments induce the regression of a pancreatic cancer cell line and a breast cancer cell line inoculated in SCID mice. Furthermore, CD31-positive cells disappear completely from tumor tissues, following treatment, indicating that neo-vascularization is entirely inhibited. These results suggest that the intra-tumoral or intra-muscular transfer of naked DNA encoding AMA might be a promising alternative modality for treating human cancers.
Rights: Nature Publishing Group, Cancer Gene Therapy, Vol.14-1, 2007, pp. 39-44
Relation: http://www.nature.com/npg/
Type: article (author version)
URI: http://hdl.handle.net/2115/25155
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小林 正伸

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