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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Peer-reviewed Journal Articles, etc >
Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential
| Title: | Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential |
| Authors: | Ito, Toshihiro Browse this author | | Couceiro, J. Nelson S. S. Browse this author | | Kelm, Sørge Browse this author | | Baum, Linda G. Browse this author | | Krauss, Scott Browse this author | | Castrucci, Maria R. Browse this author | | Donatelli, Isabella Browse this author | | Kida, Hiroshi Browse this author →KAKEN DB | | Paulson, James C. Browse this author | | Webster, Robert G. Browse this author | | Kawaoka, Yoshihiro Browse this author →KAKEN DB |
| Issue Date: | Sep-1998 |
| Publisher: | American Society for Microbiology |
| Journal Title: | Journal of Virology |
| Volume: | 72 |
| Issue: | 9 |
| Start Page: | 7367 |
| End Page: | 7373 |
| PMID: | 9696833 |
| Abstract: | Genetic and biologic observations suggest that pigs may serve as "mixing vessels" for the generation of human-avian influenza A virus reassortants, similar to those responsible for the 1957 and 1968 pandemics. Here we demonstrate a structural basis for this hypothesis. Cell surface receptors for both human and avian influenza viruses were identified in the pig trachea, providing a milieu conducive to viral replication and genetic reassortment. Surprisingly, with continued replication, some avian-like swine viruses acquired the ability to recognize human virus receptors, raising the possibility of their direct transmission to human populations. These findings help to explain the emergence of pandemic influenza viruses and support the need for continued surveillance of swine for viruses carrying avian virus genes. |
| Rights: | Copyright © 1998 American Society for Microbiology |
| Type: | article |
| URI: | http://hdl.handle.net/2115/28141 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 喜田 宏
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