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Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential

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Title: Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential
Authors: Ito, Toshihiro Browse this author
Couceiro, J. Nelson S. S. Browse this author
Kelm, Sørge Browse this author
Baum, Linda G. Browse this author
Krauss, Scott Browse this author
Castrucci, Maria R. Browse this author
Donatelli, Isabella Browse this author
Kida, Hiroshi Browse this author →KAKEN DB
Paulson, James C. Browse this author
Webster, Robert G. Browse this author
Kawaoka, Yoshihiro Browse this author →KAKEN DB
Issue Date: Sep-1998
Publisher: American Society for Microbiology
Journal Title: Journal of Virology
Volume: 72
Issue: 9
Start Page: 7367
End Page: 7373
PMID: 09696833
Abstract: Genetic and biologic observations suggest that pigs may serve as "mixing vessels" for the generation of human-avian influenza A virus reassortants, similar to those responsible for the 1957 and 1968 pandemics. Here we demonstrate a structural basis for this hypothesis. Cell surface receptors for both human and avian influenza viruses were identified in the pig trachea, providing a milieu conducive to viral replication and genetic reassortment. Surprisingly, with continued replication, some avian-like swine viruses acquired the ability to recognize human virus receptors, raising the possibility of their direct transmission to human populations. These findings help to explain the emergence of pandemic influenza viruses and support the need for continued surveillance of swine for viruses carrying avian virus genes.
Rights: Copyright © 1998 American Society for Microbiology
Type: article
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 喜田 宏

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OAI-PMH ( junii2 , jpcoar )


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