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Japanese Journal of Veterinary Research >
Volume 49, Number 4 >

Taenia taeniaeformis larval product induces gastric mucosal hyperplasia in SCID mice

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タイトル: Taenia taeniaeformis larval product induces gastric mucosal hyperplasia in SCID mice
著者: LAGAPA, Jose Trinipil G. 著作を一覧する
OKU, Yuzaburo 著作を一覧する
NONAKA, Nariaki 著作を一覧する
KAMIYA, Masao 著作を一覧する
キーワード: Taenia taeniaeformis
SCID mice
gastric hyperplasia
excretory-secretory products
発行日: 2002年 2月28日
出版者: The Graduate School of Veterinary Medicine
誌名: Japanese Journal of Veterinary Research
巻: 49
号: 4
開始ページ: 273
終了ページ: 285
抄録: The effects of intraperitoneal implantation of Taenia taeniaeformis larvae and inoculation of in vitro larval products on gastric mucosa of SCID mice were investigated in this study. Mice surgically implanted with T. taeniaeformis larvae developed slight and moderate gastric hyperplasia. When in vitro cultured T. taeniaeformis larval excretory-secretory (TtLES) products containing 1 mg of protein were injected daily into mice, they caused gastropathy after 5-7 days. Mice injected daily with 0.5mg of TtLES products also showed slight gastric hyperplasia after day 14 and 28. The gastropathy was characterized by reduction of both parietal and zymogenic cell number and increased number of alcian blue-periodic acid Schiff (AB-PAS)-positive cells and by twofold extension of proliferative zone of gastric units. Larval implantation demonstrated a more potent effect in inducing gastropathy than did in vitro larval culture products. Significant decrease in number of parietal cells with concomitant increase of proliferative zone and AB-PAS-positive cell number indicated their important roles in inducing the hyperplastic lesion. Similarities with other gastropathies indicated that there is a common fundamental regulatory mechanism involved, and that the host response may not be specific to parasites. Present study validated the induction of gastric mucosal hyperplasia by larval ES products of T. taeniaeformis. This proved the hypothesis of previous studies suggesting the role of larvae-derived products in inducing gastric mucosal hyperplasia in T. taeniaeformis-infected rats.
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出現コレクション:Volume 49, Number 4


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