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The antioxidative function of eicosapentaenoic acid in a marine bacterium, Shewanella marinintestina IK-1

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タイトル: The antioxidative function of eicosapentaenoic acid in a marine bacterium, Shewanella marinintestina IK-1
著者: Nishida, Takanori 著作を一覧する
Morita, Naoki 著作を一覧する
Yano, Yutaka 著作を一覧する
Orikasa, Yoshitake 著作を一覧する
Okuyama, Hidetoshi 著作を一覧する
キーワード: Eicosapentaenoic acid
Hydrogen peroxide
Oxidative stress
Protein carbonyl
Shewanella
発行日: 2007年 9月 4日
出版者: Elsevier B.V.
誌名: FEBS Letters
巻: 581
号: 22
開始ページ: 4212
終了ページ: 4216
出版社 DOI: 10.1016/j.febslet.2007.07.065
抄録: When the eicosapentaenoic acid (EPA)-deficient mutant strain IK-1Δ8 of the marine EPA-producing Shewanella marinintestina IK-1 was treated with various concentrations of hydrogen peroxide (H2O2), its colony-forming ability decreased more than that of the wild type. Protein carbonylation, induced by treating cells with 0.01 mM H2O2 under bacteriostatic conditions, was enhanced only in cells lacking EPA. The amount of cells recovered from the cultures was decreased more significantly by the presence of H2O2 for cells lacking EPA than for those producing EPA. Treatment of the cells with 0.1 mM H2O2 resulted in much lower intracellular concentrations of H2O2 being consistently detected in cells with EPA than in those without EPA. These results suggest that cellular EPA can directly protect cells against oxidative damage by shielding the entry of exogenously added H2O2 in S. marinintestina IK-1.
関連URI: http://www.sciencedirect.com/science/journal/00145793
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/30186
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 奥山 英登志

 

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