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The antioxidative function of eicosapentaenoic acid in a marine bacterium, Shewanella marinintestina IK-1

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Title: The antioxidative function of eicosapentaenoic acid in a marine bacterium, Shewanella marinintestina IK-1
Authors: Nishida, Takanori Browse this author
Morita, Naoki Browse this author
Yano, Yutaka Browse this author
Orikasa, Yoshitake Browse this author
Okuyama, Hidetoshi Browse this author →KAKEN DB
Keywords: Eicosapentaenoic acid
Hydrogen peroxide
Oxidative stress
Protein carbonyl
Shewanella
Issue Date: 4-Sep-2007
Publisher: Elsevier B.V.
Journal Title: FEBS Letters
Volume: 581
Issue: 22
Start Page: 4212
End Page: 4216
Publisher DOI: 10.1016/j.febslet.2007.07.065
PMID: 17706200
Abstract: When the eicosapentaenoic acid (EPA)-deficient mutant strain IK-1Δ8 of the marine EPA-producing Shewanella marinintestina IK-1 was treated with various concentrations of hydrogen peroxide (H2O2), its colony-forming ability decreased more than that of the wild type. Protein carbonylation, induced by treating cells with 0.01 mM H2O2 under bacteriostatic conditions, was enhanced only in cells lacking EPA. The amount of cells recovered from the cultures was decreased more significantly by the presence of H2O2 for cells lacking EPA than for those producing EPA. Treatment of the cells with 0.1 mM H2O2 resulted in much lower intracellular concentrations of H2O2 being consistently detected in cells with EPA than in those without EPA. These results suggest that cellular EPA can directly protect cells against oxidative damage by shielding the entry of exogenously added H2O2 in S. marinintestina IK-1.
Relation: http://www.sciencedirect.com/science/journal/00145793
Type: article (author version)
URI: http://hdl.handle.net/2115/30186
Appears in Collections:環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 奥山 英登志

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