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A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes
Title: | A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes |
Authors: | Kaneko, Masayuki Browse this author | Yasui, Saori Browse this author | Niinuma, Yoshifumi Browse this author | Arai, Kiho Browse this author | Omura, Tomohiro Browse this author | Okuma, Yasunobu Browse this author | Nomura, Yasuyuki Browse this author |
Keywords: | HRD1 | SEL1 | ER stress | ATF6 | XBP1 | ERAD |
Issue Date: | 27-Nov-2007 |
Publisher: | Elsevier Science |
Journal Title: | FEBS Letters |
Volume: | 581 |
Issue: | 28 |
Start Page: | 5355 |
End Page: | 5360 |
Publisher DOI: | 10.1016/j.febslet.2007.10.033 |
PMID: | 17967421 |
Abstract: | Human HRD1 and SEL1 are components of endoplasmic reticulum-associated degradation (ERAD), which is a retrograde transport mechanism from the ER to the cytosol for removing unfolded proteins. The expression of HRD1 and SEL1 was induced by ER stress-inducing agents and overexpression of both ER stress-responsive transcription factors, ATF6 and XBP1. Inhibition of IRE1 and ATF6 revealed that ER stress-induced HRD1 and SEL1 expressions are mediated by IRE1-XBP1- and ATF6-dependent pathways, respectively. These results suggest that the ER stress-induced ERAD gene expressions are mediated by different pathways, which are attributed to the differences in the promoter regions. |
Relation: | http://www.sciencedirect.com/science/journal/00145793 |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/32746 |
Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 野村 靖幸
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