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A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/32746

Title: A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes
Authors: Kaneko, Masayuki Browse this author
Yasui, Saori Browse this author
Niinuma, Yoshifumi Browse this author
Arai, Kiho Browse this author
Omura, Tomohiro Browse this author
Okuma, Yasunobu Browse this author
Nomura, Yasuyuki Browse this author
Keywords: HRD1
SEL1
ER stress
ATF6
XBP1
ERAD
Issue Date: 27-Nov-2007
Publisher: Elsevier Science
Journal Title: FEBS Letters
Volume: 581
Issue: 28
Start Page: 5355
End Page: 5360
Publisher DOI: 10.1016/j.febslet.2007.10.033
PMID: 17967421
Abstract: Human HRD1 and SEL1 are components of endoplasmic reticulum-associated degradation (ERAD), which is a retrograde transport mechanism from the ER to the cytosol for removing unfolded proteins. The expression of HRD1 and SEL1 was induced by ER stress-inducing agents and overexpression of both ER stress-responsive transcription factors, ATF6 and XBP1. Inhibition of IRE1 and ATF6 revealed that ER stress-induced HRD1 and SEL1 expressions are mediated by IRE1-XBP1- and ATF6-dependent pathways, respectively. These results suggest that the ER stress-induced ERAD gene expressions are mediated by different pathways, which are attributed to the differences in the promoter regions.
Relation: http://www.sciencedirect.com/science/journal/00145793
Type: article (author version)
URI: http://hdl.handle.net/2115/32746
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 野村 靖幸

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