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Memory and Decision Making in the Frontal Cortex during Visual Motion Processing for Smooth Pursuit Eye Movements

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Title: Memory and Decision Making in the Frontal Cortex during Visual Motion Processing for Smooth Pursuit Eye Movements
Authors: Shichinohe, Natsuko Browse this author
Akao, Teppei Browse this author
Kurkin, Sergei Browse this author →KAKEN DB
Fukushima, Junko Browse this author →KAKEN DB
Kaneko, Chris R. S. Browse this author
Fukushima, Kikuro Browse this author →KAKEN DB
Keywords: Frontal cortex
Supplementary eye fields
Smooth pursuit
Visual motion
Memory
Decision-making
Movement preparation, Monkey
Issue Date: 11-Jun-2009
Publisher: Cell Press
Journal Title: Neuron
Volume: 62
Issue: 5
Start Page: 717
End Page: 732
Publisher DOI: 10.1016/j.neuron.2009.05.010
Abstract: Cortical motor areas are thought to contribute "higher-order processing" but what that processing might include is unknown. Previous studies of the smooth pursuit-related discharge of supplementary eye field (SEF) neurons did not distinguish activity associated with the preparation for pursuit from discharge related to processing or memory of the target motion signals. Using a new, memory-based task, which was designed to separate these components, we show that the SEF contains signals coding retinal image-slip-velocity, memory and assessment of visual motion-direction, the decision of whether or not to pursue, and the preparation for pursuit eye movements. Bilateral muscimol injection into SEF resulted in directional errors in smooth pursuit, errors of whether or not to pursue, and impairment of initial correct eye movements. These results suggest an important role for the SEF in memory and assessment of visual motion-direction and the programming of appropriate pursuit eye movements.
Type: article (author version)
URI: http://hdl.handle.net/2115/38756
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 福島 菊郎

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