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Memory and Decision Making in the Frontal Cortex during Visual Motion Processing for Smooth Pursuit Eye Movements
Title: | Memory and Decision Making in the Frontal Cortex during Visual Motion Processing for Smooth Pursuit Eye Movements |
Authors: | Shichinohe, Natsuko Browse this author | Akao, Teppei Browse this author | Kurkin, Sergei Browse this author →KAKEN DB | Fukushima, Junko Browse this author →KAKEN DB | Kaneko, Chris R. S. Browse this author | Fukushima, Kikuro Browse this author →KAKEN DB |
Keywords: | Frontal cortex | Supplementary eye fields | Smooth pursuit | Visual motion | Memory | Decision-making | Movement preparation, Monkey |
Issue Date: | 11-Jun-2009 |
Publisher: | Cell Press |
Journal Title: | Neuron |
Volume: | 62 |
Issue: | 5 |
Start Page: | 717 |
End Page: | 732 |
Publisher DOI: | 10.1016/j.neuron.2009.05.010 |
Abstract: | Cortical motor areas are thought to contribute "higher-order processing" but what that processing might include is unknown. Previous studies of the smooth pursuit-related discharge of supplementary eye field (SEF) neurons did not distinguish activity associated with the preparation for pursuit from discharge related to processing or memory of the target motion signals. Using a new, memory-based task, which was designed to separate these components, we show that the SEF contains signals coding retinal image-slip-velocity, memory and assessment of visual motion-direction, the decision of whether or not to pursue, and the preparation for pursuit eye movements. Bilateral muscimol injection into SEF resulted in directional errors in smooth pursuit, errors of whether or not to pursue, and impairment of initial correct eye movements. These results suggest an important role for the SEF in memory and assessment of visual motion-direction and the programming of appropriate pursuit eye movements. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/38756 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 福島 菊郎
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