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Synthesis of 2-Substituted Cyclohexene Derivatives through Cross-Coupling Reactions via π-Allylmetal Intermediate Using N-Heterocyclic Carbenes (NHCs) as Ligands

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Title: Synthesis of 2-Substituted Cyclohexene Derivatives through Cross-Coupling Reactions via π-Allylmetal Intermediate Using N-Heterocyclic Carbenes (NHCs) as Ligands
Authors: Yamazaki, Tetsuro Browse this author
Sato, Yoshihiro Browse this author
Keywords: N-heterocyclic carbene (NHC)
cross-coupling
Migita-Kosugi-Stille reaction
Kumada-Tamao-Coriiu reaction
palladium
nickel
Issue Date: Sep-2008
Publisher: Georg Thieme Verlag KG
Journal Title: Synthesis : international journal of methods in synthetic organic chemistry
Volume: 2008
Issue: 17
Start Page: 2830
End Page: 2834
Publisher DOI: 10.1055/s-2008-1067222
Abstract: Palladium- or nickel-catalyzed cross-coupling reactions of 2-substituted cyclohexenes, which are generally less reactive than those having no substituent at the C2 position, with organotin reagents (Migita-Kosugi-Stille coupling) or with Grigard reagents (Kumada-Tamao-Corriu coupling) using a NHC as a ligand was investigated. It was found that NHCs are effective as ligands for these reactions, giving the corresponding cross-coupling products in good yields.
Rights: © 2008 Georg Thieme Verlag KG.
Type: article (author version)
URI: http://hdl.handle.net/2115/39134
Appears in Collections:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐藤 美洋

 

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