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Synthesis of 2-Substituted Cyclohexene Derivatives through Cross-Coupling Reactions via π-Allylmetal Intermediate Using N-Heterocyclic Carbenes (NHCs) as Ligands
| Title: | Synthesis of 2-Substituted Cyclohexene Derivatives through Cross-Coupling Reactions via π-Allylmetal Intermediate Using N-Heterocyclic Carbenes (NHCs) as Ligands |
| Authors: | Yamazaki, Tetsuro Browse this author | | Sato, Yoshihiro Browse this author |
| Keywords: | N-heterocyclic carbene (NHC) | | cross-coupling | | Migita-Kosugi-Stille reaction | | Kumada-Tamao-Coriiu reaction | | palladium | | nickel |
| Issue Date: | Sep-2008 |
| Publisher: | Georg Thieme Verlag KG |
| Journal Title: | Synthesis : international journal of methods in synthetic organic chemistry |
| Volume: | 2008 |
| Issue: | 17 |
| Start Page: | 2830 |
| End Page: | 2834 |
| Publisher DOI: | 10.1055/s-2008-1067222 |
| Abstract: | Palladium- or nickel-catalyzed cross-coupling reactions of 2-substituted cyclohexenes, which are generally less reactive than those having no substituent at the C2 position, with organotin reagents (Migita-Kosugi-Stille coupling) or with Grigard reagents (Kumada-Tamao-Corriu coupling) using a NHC as a ligand was investigated. It was found that NHCs are effective as ligands for these reactions, giving the corresponding cross-coupling products in good yields. |
| Rights: | © 2008 Georg Thieme Verlag KG. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/39134 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 佐藤 美洋
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