Increase in Deformability of Human Erythrocytes through the Action of β-Lysophospholipid Rich in n-3 Polyunsaturated Fatty Acid Content

Hosokawa, Masashi; Ono, Masayo; Takahashi, Koretaro; Inoue, Yoshikazu

doi:10.5650/jos1996.47.1313


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Increase in Deformability of Human Erythrocytes through the Action of β-Lysophospholipid Rich in n-3 Polyunsaturated Fatty Acid Content

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Title:	Increase in Deformability of Human Erythrocytes through the Action of β-Lysophospholipid Rich in n-3 Polyunsaturated Fatty Acid Content
Other Titles:	n-3系多価不飽和脂肪酸高含有β-リゾリン脂質によるヒト赤血球変形能の増進作用
Authors:	Hosokawa, Masashi¹ Browse this author →KAKEN DB
	Ono, Masayo² Browse this author
	Takahashi, Koretaro³ Browse this author →KAKEN DB
	Inoue, Yoshikazu⁴ Browse this author
Authors(alt):	細川, 雅史¹
	小野, 雅代²
	高橋, 是太郎³
	井上, 良計⁴
Keywords:	phospholipids
	docosahexaenoic acid
	eicosapentaenoic acid
	erythrocyte
	deformability
Issue Date:	20-Dec-1998
Publisher:	日本油化学会
Journal Title:	日本油化学会誌
Journal Title(alt):	Journal of Japan Oil Chemists' Society
Volume:	47
Issue:	12
Start Page:	1313
End Page:	1318
Publisher DOI:	10.5650/jos1996.47.1313
Abstract:	Lysophosphatidylcholine (LPC) that binds to docosahexaenoic acid (DHA) at the sn-2 position (β-DHA-LPC) was prepared by the Lipozyme mediated selective partial hydrolysis of DHA-enriched egg yolk lecithin. The β-DHA-LPC was found to be rapidly incorporated into erythrocyte cells and increase their deformability at 5μM/erythrocyte.
Abstract:	リポザイム（ケカビ由来固定化酵素）を用いたドコサヘキサエン酸 (DHA) 強化鶏卵黄ホスファチジルコリン (PC) の選択的部分加水分解反応により，sn-2位にDHAの結合したリゾホスファチジルコリン (β-DHA-LPC) を調製した。このβ-DHA-LPCは，ヒト赤血球懸濁液に対し5μMの濃度においても，速やかにヒト赤血球中に取り込まれ，その変形能を向上させることができることを人工毛細血管モデルにより明らかにした。
Description:	報文
Type:	article
URI:	http://hdl.handle.net/2115/42716
Appears in Collections:	水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高橋是太郎

OAI-PMH ( junii2 , jpcoar_1.0 )

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