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Power-Law Stress and Creep Relaxations of Single Cells Measured by Colloidal Probe Atomic Force Microscopy

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Title: Power-Law Stress and Creep Relaxations of Single Cells Measured by Colloidal Probe Atomic Force Microscopy
Authors: Hiratsuka, Shinichiro Browse this author
Mizutani, Yusuke Browse this author
Toda, Akitoshi Browse this author
Fukushima, Norichika Browse this author
Kawahara, Koichi Browse this author
Tokumoto, Hiroshi Browse this author →KAKEN DB
Okajima, Takaharu Browse this author →KAKEN DB
Issue Date: Aug-2009
Publisher: Japan Society of Applied Physics
Journal Title: Japanese Journal of Applied Physics
Volume: 48
Issue: 8
Start Page: 08JB17
Publisher DOI: 10.1143/JJAP.48.08JB17
Abstract: We measured stress and creep relaxations of mouse fibroblast cells arranged and cultured on a microarray, by colloidal probe atomic force microscopy (AFM). A hydrophobic monolayer coating of perfluorodecyltrichlorosilane (FDTS) on the surface of colloidal silica beads significantly reduced the adhesion force of live cells, compared with untreated beads. The rheological behaviors of cells were estimated by averaging several relaxation curves of cells measured by the AFM. Longer-time tailing of both stress and creep relaxation curves followed single power-law behavior over a time scale of 60 s, with exponents in the range 0.1–0.4, varying with cells. The results were in good agreement with previous measurements of the frequency-domain rheology of cells using the force modulation mode.
Relation: http://jjap.jsap.jp/link?JJAP/48/08JB17/
Type: article (author version)
URI: http://hdl.handle.net/2115/45747
Appears in Collections:情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岡嶋 孝治

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