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Rheological Properties of Growth-Arrested Fibroblast Cells under Serum Starvation Measured by Atomic Force Microscopy

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Title: Rheological Properties of Growth-Arrested Fibroblast Cells under Serum Starvation Measured by Atomic Force Microscopy
Authors: Miyaoka, Atsushi Browse this author
Mizutani, Yusuke Browse this author
Tsuchiya, Masahiro Browse this author
Kawahara, Koichi Browse this author →KAKEN DB
Okajima, Takaharu Browse this author →KAKEN DB
Issue Date: Aug-2011
Publisher: Japan Society of Applied Physics
Journal Title: Japanese Journal of Applied Physics
Volume: 50
Issue: 8
Start Page: 08LB16-1
End Page: 08LB16-5
Publisher DOI: 10.1143/JJAP.50.08LB16
Abstract: The rheological properties of growth-arrested and quiescent (G0 phase) mouse fibroblast cells under serum starvation were investigated by atomic force microscopy (AFM) with a microarray technique. The number distribution of complex shear modulus, G*, of quiescent cells at the serum concentration, CS = 0.1%, followed a log-normal distribution, and the frequency dependence of G* exhibited a power law behavior, which were similar to those under a control condition at CS = 10%. On the other hand, we found that the Newtonian viscosity coefficient of the quiescent cells significantly increased, and the distribution broadened, as compared with the control cells, whereas the power-law exponent was unchanged. The result indicated that the rheological properties of quiescent fibroblast cells were not identical to those in the G1 phase during cell cycle. This finding suggests that the Newtonian viscosity of cells is one of the useful indicators for evaluating growth-arrested cells under serum starvation.
Rights: ©2011 The Japan Society of Applied Physics
Relation: http://jjap.jsap.jp/link?JJAP/50/08LB16/
Type: article (author version)
URI: http://hdl.handle.net/2115/47050
Appears in Collections:情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岡嶋 孝治

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