HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Information Science and Technology / Faculty of Information Science and Technology >
Peer-reviewed Journal Articles, etc >

Inducible astrocytic glucose transporter-3 contributes to the enhanced storage of intracellular glycogen during reperfusion after ischemia

Files in This Item:
NI59-2_319-325.pdf494.39 kBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/47134

Title: Inducible astrocytic glucose transporter-3 contributes to the enhanced storage of intracellular glycogen during reperfusion after ischemia
Authors: Iwabuchi, Sadahiro Browse this author
Kawahara, Koichi Browse this author →KAKEN DB
Keywords: Astrocytes
GLUT3
GLUT1
Ischemic stress
Glycogen
Issue Date: Aug-2011
Publisher: Elsevier B.V.
Journal Title: Neurochemistry International
Volume: 59
Issue: 2
Start Page: 319
End Page: 325
Publisher DOI: 10.1016/j.neuint.2011.06.006
PMID: 21703319
Abstract: Glucose is a necessary source of energy to sustain cell activities and homeostasis in the brain, and enhanced glucose transporter (GLUT) activities are protective of cells during energy depletion including brain ischemia. Here we investigated whether and if so how the astrocytic expression of GLUTs crucial for the uptake of glucose changes in ischemic conditions. Under physiological conditions, cultured astrocytes primarily expressed GLUT1, and GLUT3 was only detected at extremely low levels. However, exposure to ischemic stress increased the expression of not only GLUT1 but also GLUT3. During ischemia, cultured astrocytes significantly increased production of the transcription factor nuclear factor-κB (NF-κB), leading to an increase in GLUT3 expression. Moreover, astrocytic GLUT3 was responsible for the enhanced storage of intracellular glucose during reperfusion, resulting in increased resistance to lethal ischemic stress. These results suggested that astrocytes promptly increase GLUT3 production in situations such as ischemia, and much glucose is quickly taken up, possibly contributing to the protection of astrocytes from ischemic damage.
Type: article (author version)
URI: http://hdl.handle.net/2115/47134
Appears in Collections:情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 河原 剛一

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 

 - Hokkaido University