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Protective Effect of Soy Isoflavone Genistein on Ischemia-Reperfusion in the Rat Small Intestine

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/47199

Title: Protective Effect of Soy Isoflavone Genistein on Ischemia-Reperfusion in the Rat Small Intestine
Authors: Sato, Yuki Browse this author
Itagaki, Shirou Browse this author
Oikawa, Setsu Browse this author
Ogura, Jiro Browse this author
Kobayashi, Masaki Browse this author →KAKEN DB
Hirano, Takeshi Browse this author
Sugawara, Mitsuru Browse this author
Iseki, Ken Browse this author
Keywords: genistein
ischemia-reperfusion
antioxidant
intestine
nutrition
Issue Date: Sep-2011
Publisher: Pharmaceutical Society of Japan
Journal Title: Biological & Pharmaceutical Bulletin
Volume: 34
Issue: 9
Start Page: 1448
End Page: 1454
Publisher DOI: 10.1248/bpb.34.1448
Abstract: Ischemia-reperfusion (I/R) injury of the intestine is an important factor associated with high rates of morbidity and mortality. Intestinal I/R is a common clinical problem in the settings of severe burns, circulatory shock and strangulation ileus. Intestinal I/R damages remote organs and promotes multi-organ failure. It has been shown that enteral feeding before ischemic insults is beneficial for reducing organ injury and improving survival after intestinal I/R. In that study, the authors used a standard complex enteral diet and they suggested that it is important to find new nutrient formulas. Since reactive oxygen species are responsible for intestinal I/R injury, we focused on a dietary polyphenol, the soy isoflavone genistein. Genistein has a wide spectrum of biochemical and pharmacological activities. However, the possibility of a protective effect of genistein as enteral nutrition on I/R injury has not been investigated. We therefore investigated the protective effect of genistein on oxidative injury using intestinal I/R model rats. We found that genistein, which has combined antioxidant activity from radical scavenging, xanthine oxidase inhibition and chain-breaking effects, exhibits a protective effect on intestinal I/R injury. The results suggest that genistein, a soy isoflavone, has the possibility as a new nutrient formula of enteral feeding.
Type: article
URI: http://hdl.handle.net/2115/47199
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小林 正紀

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