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Protective Effect of Soy Isoflavone Genistein on Ischemia-Reperfusion in the Rat Small Intestine
| Title: | Protective Effect of Soy Isoflavone Genistein on Ischemia-Reperfusion in the Rat Small Intestine |
| Authors: | Sato, Yuki Browse this author | | Itagaki, Shirou Browse this author | | Oikawa, Setsu Browse this author | | Ogura, Jiro Browse this author | | Kobayashi, Masaki Browse this author →KAKEN DB | | Hirano, Takeshi Browse this author | | Sugawara, Mitsuru Browse this author | | Iseki, Ken Browse this author |
| Keywords: | genistein | | ischemia-reperfusion | | antioxidant | | intestine | | nutrition |
| Issue Date: | Sep-2011 |
| Publisher: | Pharmaceutical Society of Japan |
| Journal Title: | Biological & Pharmaceutical Bulletin |
| Volume: | 34 |
| Issue: | 9 |
| Start Page: | 1448 |
| End Page: | 1454 |
| Publisher DOI: | 10.1248/bpb.34.1448 |
| Abstract: | Ischemia-reperfusion (I/R) injury of the intestine is an important factor associated with high rates of morbidity and mortality. Intestinal I/R is a common clinical problem in the settings of severe burns, circulatory shock and strangulation ileus. Intestinal I/R damages remote organs and promotes multi-organ failure. It has been shown that enteral feeding before ischemic insults is beneficial for reducing organ injury and improving survival after intestinal I/R. In that study, the authors used a standard complex enteral diet and they suggested that it is important to find new nutrient formulas. Since reactive oxygen species are responsible for intestinal I/R injury, we focused on a dietary polyphenol, the soy isoflavone genistein. Genistein has a wide spectrum of biochemical and pharmacological activities. However, the possibility of a protective effect of genistein as enteral nutrition on I/R injury has not been investigated. We therefore investigated the protective effect of genistein on oxidative injury using intestinal I/R model rats. We found that genistein, which has combined antioxidant activity from radical scavenging, xanthine oxidase inhibition and chain-breaking effects, exhibits a protective effect on intestinal I/R injury. The results suggest that genistein, a soy isoflavone, has the possibility as a new nutrient formula of enteral feeding. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/47199 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 小林 正紀
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