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Lower aerobic capacity was associated with abnormal intramuscular energetics in patients with metabolic syndrome
| Title: | Lower aerobic capacity was associated with abnormal intramuscular energetics in patients with metabolic syndrome |
| Authors: | Yokota, Takashi Browse this author | | Kinugawa, Shintaro Browse this author →KAKEN DB | | Okita, Koichi Browse this author | | Hirabayashi, Kagami Browse this author | | Suga, Tadashi Browse this author | | Hattori, Masaaki Browse this author | | Nakagawa, Yoshinao Browse this author | | Oyama-Manabe, Noriko Browse this author | | Shirato, Hiroki Browse this author | | Tsutsui, Hiroyuki Browse this author |
| Keywords: | energy metabolism | | exercise | | metabolic syndrome | | muscles |
| Issue Date: | Sep-2011 |
| Publisher: | Nature Publishing Group |
| Journal Title: | Hypertension Research |
| Volume: | 34 |
| Issue: | 9 |
| Start Page: | 1029 |
| End Page: | 1034 |
| Publisher DOI: | 10.1038/hr.2011.78 |
| PMID: | 21753774 |
| Abstract: | Lower aerobic capacity is a strong and independent predictor of cardiovascular morbidity and mortality in patients with metabolic syndrome (MetS). However, the mechanisms are not fully elucidated. We tested the hypothesis that skeletal muscle dysfunction could contribute to the lower aerobic capacity in MetS patients. The incremental exercise tests with cycle ergometer were performed in 12 male patients with MetS with no habitual exercise and 11 age-, sex-, and activity-matched control subjects to assess the aerobic capacity. We performed 31phosphorus-magnetic resonance spectroscopy (31P-MRS) to assess the high-energy phosphate metabolism in skeletal muscle during aerobic exercise. Proton(1H)-MRS was also performed to measure intramyocellular lipid (IMCL) content. Peak oxygen uptake (peak VO2; 34.1 ± 6.2 vs. 41.4 ± 8.4 mL/kg/min, P < 0.05) and anaerobic threshold (AT; 18.0 ± 2.4 vs. 23.1 ± 3.7 mL/kg/min, P < 0.01) adjusted by lean body mass were lower in MetS patients than control subjects. Phosphocreatine (PCr) loss during exercise was 1.5-fold greater in MetS, suggesting reduced intramuscular oxidative capacity. PCr loss was inversely correlated with peak VO2 (r = -0.64) and AT (r = -0.60), respectively. IMCL content was 3-fold higher in MetS and was inversely correlated with peak VO2 (r = -0.47) and AT (r = -0.52), respectively. Moreover, there was a positive correlation between IMCL content and PCr loss (r = 0.64). These results suggested that lean-body aerobic capacity in MetS patients was lower compared with activity-matched healthy subjects, which might be due to the reduced intramuscular fatty acid oxidative metabolism. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/48494 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 絹川 真太郎
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