HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >

Lower aerobic capacity was associated with abnormal intramuscular energetics in patients with metabolic syndrome

Files in This Item:
HR34-9_1029-1034.pdf294.75 kBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/48494

Title: Lower aerobic capacity was associated with abnormal intramuscular energetics in patients with metabolic syndrome
Authors: Yokota, Takashi Browse this author
Kinugawa, Shintaro Browse this author →KAKEN DB
Okita, Koichi Browse this author
Hirabayashi, Kagami Browse this author
Suga, Tadashi Browse this author
Hattori, Masaaki Browse this author
Nakagawa, Yoshinao Browse this author
Oyama-Manabe, Noriko Browse this author
Shirato, Hiroki Browse this author
Tsutsui, Hiroyuki Browse this author
Keywords: energy metabolism
exercise
metabolic syndrome
muscles
Issue Date: Sep-2011
Publisher: Nature Publishing Group
Journal Title: Hypertension Research
Volume: 34
Issue: 9
Start Page: 1029
End Page: 1034
Publisher DOI: 10.1038/hr.2011.78
PMID: 21753774
Abstract: Lower aerobic capacity is a strong and independent predictor of cardiovascular morbidity and mortality in patients with metabolic syndrome (MetS). However, the mechanisms are not fully elucidated. We tested the hypothesis that skeletal muscle dysfunction could contribute to the lower aerobic capacity in MetS patients. The incremental exercise tests with cycle ergometer were performed in 12 male patients with MetS with no habitual exercise and 11 age-, sex-, and activity-matched control subjects to assess the aerobic capacity. We performed 31phosphorus-magnetic resonance spectroscopy (31P-MRS) to assess the high-energy phosphate metabolism in skeletal muscle during aerobic exercise. Proton(1H)-MRS was also performed to measure intramyocellular lipid (IMCL) content. Peak oxygen uptake (peak VO2; 34.1 ± 6.2 vs. 41.4 ± 8.4 mL/kg/min, P < 0.05) and anaerobic threshold (AT; 18.0 ± 2.4 vs. 23.1 ± 3.7 mL/kg/min, P < 0.01) adjusted by lean body mass were lower in MetS patients than control subjects. Phosphocreatine (PCr) loss during exercise was 1.5-fold greater in MetS, suggesting reduced intramuscular oxidative capacity. PCr loss was inversely correlated with peak VO2 (r = -0.64) and AT (r = -0.60), respectively. IMCL content was 3-fold higher in MetS and was inversely correlated with peak VO2 (r = -0.47) and AT (r = -0.52), respectively. Moreover, there was a positive correlation between IMCL content and PCr loss (r = 0.64). These results suggested that lean-body aerobic capacity in MetS patients was lower compared with activity-matched healthy subjects, which might be due to the reduced intramuscular fatty acid oxidative metabolism.
Type: article (author version)
URI: http://hdl.handle.net/2115/48494
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 絹川 真太郎

Export metadata:

OAI-PMH ( junii2 , jpcoar )


 

Feedback - Hokkaido University