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Tyk2 deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice
| Title: | Tyk2 deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice |
| Authors: | Ishizaki, Masayuki Browse this author | | Muromoto, Ryuta Browse this author →KAKEN DB | | Akimoto, Toshihiko Browse this author | | Ohshiro, Yuya Browse this author | | Takahashi, Miki Browse this author | | Sekine, Yuichi Browse this author →KAKEN DB | | Maeda, Hiroaki Browse this author | | Shimoda, Kazuya Browse this author →KAKEN DB | | Oritani, Kenji Browse this author →KAKEN DB | | Matsuda, Tadashi Browse this author →KAKEN DB |
| Keywords: | Tyk2 | | anti-type II collagen antibody-induced arthritis | | rheumatoid arthritis |
| Issue Date: | Jul-2011 |
| Publisher: | Oxford University Press |
| Journal Title: | International Immunology |
| Volume: | 23 |
| Issue: | 9 |
| Start Page: | 575 |
| End Page: | 582 |
| Publisher DOI: | 10.1093/intimm/dxr057 |
| PMID: | 21765170 |
| Abstract: | Tyrosine kinase-2 (Tyk2) participates in the signaling pathways of multiple cytokines in innate and acquired immunity. In the present study, we investigated in the in vivo involvement of Tyk2 in anti-type II collagen antibody-induced arthritis (CAIA) using Tyk2-deficient mice. Hind paws of wild-type mice showed massive swelling and erythema by arthritogenic antibody injection, while Tyk2 deficient mice did not show any signs of arthritis. Indeed, neither the infiltration of inflammatory cells nor the fibrillation of articular cartilages was observed in Tyk2-deficient mice. Tyk2 deficiency also reduced the production of Th1/Th17-related cytokines, the other pro-inflammatory cytokines and matrix metalloproteases, which are induced in the CAIA paw. Our results demonstrate a critical contribution of Tyk2 in the development of arthritis, and we propose that Tyk2 might be an important candidate for drug development. |
| Description: | 2012年7月(出版12ヶ月後)公開 |
| Rights: | This is a pre-copy-editing, author-produced PDF of an article accepted for publication in International Immunology following peer review. The definitive publisher-authenticated version "International Immunology 2011 23(9):575-582" is available online at: http://intimm.oxfordjournals.org/content/23/9/575. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/49521 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 正
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