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Tyk2 deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice

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Title: Tyk2 deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice
Authors: Ishizaki, Masayuki Browse this author
Muromoto, Ryuta Browse this author →KAKEN DB
Akimoto, Toshihiko Browse this author
Ohshiro, Yuya Browse this author
Takahashi, Miki Browse this author
Sekine, Yuichi Browse this author →KAKEN DB
Maeda, Hiroaki Browse this author
Shimoda, Kazuya Browse this author →KAKEN DB
Oritani, Kenji Browse this author →KAKEN DB
Matsuda, Tadashi Browse this author →KAKEN DB
Keywords: Tyk2
anti-type II collagen antibody-induced arthritis
rheumatoid arthritis
Issue Date: Jul-2011
Publisher: Oxford University Press
Journal Title: International Immunology
Volume: 23
Issue: 9
Start Page: 575
End Page: 582
Publisher DOI: 10.1093/intimm/dxr057
PMID: 21765170
Abstract: Tyrosine kinase-2 (Tyk2) participates in the signaling pathways of multiple cytokines in innate and acquired immunity. In the present study, we investigated in the in vivo involvement of Tyk2 in anti-type II collagen antibody-induced arthritis (CAIA) using Tyk2-deficient mice. Hind paws of wild-type mice showed massive swelling and erythema by arthritogenic antibody injection, while Tyk2 deficient mice did not show any signs of arthritis. Indeed, neither the infiltration of inflammatory cells nor the fibrillation of articular cartilages was observed in Tyk2-deficient mice. Tyk2 deficiency also reduced the production of Th1/Th17-related cytokines, the other pro-inflammatory cytokines and matrix metalloproteases, which are induced in the CAIA paw. Our results demonstrate a critical contribution of Tyk2 in the development of arthritis, and we propose that Tyk2 might be an important candidate for drug development.
Description: 2012年7月(出版12ヶ月後)公開
Rights: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in International Immunology following peer review. The definitive publisher-authenticated version "International Immunology 2011 23(9):575-582" is available online at:
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

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