| Title: | Interleukin-17A Deficiency Accelerates Unstable Atherosclerotic Plaque Formation in Apolipoprotein E-Deficient Mice |
| Authors: | Danzaki, Keiko Browse this author |
| Matsui, Yutaka Browse this author →KAKEN DB |
| Ikesue, Masahiro Browse this author |
| Ohta, Daichi Browse this author |
| Ito, Koyu Browse this author |
| Kanayama, Masashi Browse this author |
| Kurotaki, Daisuke Browse this author |
| Morimoto, Junko Browse this author →KAKEN DB |
| Iwakura, Yoichiro Browse this author |
| Yagita, Hideo Browse this author |
| Tsutsui, Hiroyuki Browse this author →KAKEN DB |
| Uede, Toshimitsu Browse this author →KAKEN DB |
| Keywords: | atherosclerosis |
| CD4 positive T cells |
| high fat diet |
| interferon gamma |
| interleukin-17A |
| IL-17A |
| IFN-γ |
| Issue Date: | Feb-2012 |
| Publisher: | American Heart Association |
| Journal Title: | Arteriosclerosis, Thrombosis, and Vascular Biology |
| Volume: | 32 |
| Issue: | 2 |
| Start Page: | 273 |
| End Page: | 280 |
| Publisher DOI: | 10.1161/ATVBAHA.111.229997 |
| PMID: | 22116098 |
| Abstract: | Objective: Interleukin-17A (IL-17A), an inflammatory cytokine, has been implicated in atherosclerosis, in which inflammatory cells within atherosclerotic plaques express IL-17A. However, its role in the development of atheroscelrosis remains to be controversial. Methods and Results: To directly examine the role of IL-17A in atherosclerosis, we generated apolipoprotein E (ApoE)/IL-17A double-deficient (ApoE^[-/-]IL-17A^[-/-]) mice. Mice were fed with high-fat diet (HFD) for either 8 or 16 weeks, both starting at ages of 6-8 weeks. We found that splenic CD4+ T cells produced high amounts of IL-17A in ApoE^[-/-] mice after HFD feeding for 8 weeks. Atherosclerosis was significantly accelerated in HFD-fed ApoE^[-/-]IL-17A^[-/-] mice compared with ApoE^[-/-] mice. Splenic CD4+ T-cells of ApoE^[-/-]IL-17A^[-/-] mice after HFD feeding for 8 weeks, but not for 16 weeks, exhibited increased IFN-γ and decreased IL-5 production. Importantly, formation of vulnerable plaque as evidenced by reduced numbers of vascular smooth muscle cells and reduced type I collagen deposition in the plaque was detected in ApoE^[-/-]IL-17A^[-/-] mice after HFD feeding for 8 weeks. Conclusions: These results suggest that IL-17A regulates the early phase of atherosclerosis development after HFD feeding and plaque stability, at least partly if not all by modulating IFN-γ and IL-5 production from CD4+ T-cells. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/49684 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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