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Clinical features of spinal cord sarcoidosis : analysis of 17 neurosarcoidosis patients

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Title: Clinical features of spinal cord sarcoidosis : analysis of 17 neurosarcoidosis patients
Authors: Sakushima, Ken Browse this author
Yabe, Ichiro Browse this author →KAKEN DB
Nakano, Fumihito Browse this author
Yoshida, Kazuto Browse this author
Tajima, Yasutaka Browse this author
Houzen, Hideki Browse this author
Maruo, Yasunori Browse this author
Sasaki, Hidenao Browse this author →KAKEN DB
Keywords: Neurosarcoidosis
Spinal cord sarcoidosis
Cerebrospinal fluid
Angiotensin-converting enzyme
Issue Date: Dec-2011
Publisher: Springer-Verlag
Journal Title: Journal of Neurology
Volume: 258
Issue: 12
Start Page: 2163
End Page: 2167
Publisher DOI: 10.1007/s00415-011-6080-3
PMID: 21553080
Abstract: The diagnosis of neurosarcoidosis is often difficult; the imaging signs of spinal cord sarcoidosis sometimes mimic those of cervical spondylotic myelopathy, which is common in elderly persons. We examined the characteristics of spinal cord sarcoidosis in Japanese patients with neurosarcoidosis. This case series identified patients with neurosarcoidosis at 4 general hospitals and 1 university hospital from April 1998 to September 2010. All diagnoses were based on the diagnostic criteria proposed by Zajicek et al. Seventeen patients (9 men and 8 women) were involved: 6 patients with spinal cord lesions accompanied by cervical spondylosis, 5 with cerebral lesions, 3 with cranial nerve lesions, 2 with meningitis, and 1, with nerve root lesions. Patients with spinal cord sarcoidosis had a higher onset age, longer duration from onset to diagnosis, reduced leukocytosis in the cerebrospinal fluid (CSF), and lower angiotensin-converting enzyme (ACE) levels in the CSF. The results of this study indicate that diagnosis of spinal cord sarcoidosis requires careful evaluation.
Rights: The original publication is available at
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐久嶋 研

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