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Regulatory mechanisms of nucleic acid-mediated innate immune responses in the tumor microenvironment

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/52687

Title: Regulatory mechanisms of nucleic acid-mediated innate immune responses in the tumor microenvironment
Authors: Jinushi, Masahisa Browse this author
Keywords: dendritic cells
HMGB1
innate immunity
nucleic acids
TIM-3
Issue Date: Dec-2012
Publisher: Lande Bioscience
Journal Title: OncoImmunology
Volume: 1
Issue: 9
Start Page: 1632
End Page: 1634
Publisher DOI: 10.4161/onci.21681
Abstract: We identified novel mechanisms whereby TIM-3 suppresses innate immunity as induced by nucleic acids. Interaction of TIM-3 with HMGB1 inhibits the recruitment of nucleic acids to the endosomal compartment of dendritic cells, impairing the transduction of innate immune signals. Thus, TIM-3 is an effective target for enhancing the immunogenicity of nucleic acids in the context of cancer therapy.
Type: article (author version)
URI: http://hdl.handle.net/2115/52687
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 地主 将久

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