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Hokkaido University Collection of Scholarly and Academic Papers >
Institute for Genetic Medicine >
Peer-reviewed Journal Articles, etc >
Regulatory mechanisms of nucleic acid-mediated innate immune responses in the tumor microenvironment
| Title: | Regulatory mechanisms of nucleic acid-mediated innate immune responses in the tumor microenvironment |
| Authors: | Jinushi, Masahisa Browse this author |
| Keywords: | dendritic cells | | HMGB1 | | innate immunity | | nucleic acids | | TIM-3 |
| Issue Date: | Dec-2012 |
| Publisher: | Lande Bioscience |
| Journal Title: | OncoImmunology |
| Volume: | 1 |
| Issue: | 9 |
| Start Page: | 1632 |
| End Page: | 1634 |
| Publisher DOI: | 10.4161/onci.21681 |
| Abstract: | We identified novel mechanisms whereby TIM-3 suppresses innate immunity as induced by nucleic acids. Interaction of TIM-3 with HMGB1 inhibits the recruitment of nucleic acids to the endosomal compartment of dendritic cells, impairing the transduction of innate immune signals. Thus, TIM-3 is an effective target for enhancing the immunogenicity of nucleic acids in the context of cancer therapy. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/52687 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 地主 将久
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