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Predominant prevalence of arterial thrombosis in Japanese patients with antiphospholipid syndrome

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タイトル: Predominant prevalence of arterial thrombosis in Japanese patients with antiphospholipid syndrome
著者: Fujieda, Yuichiro 著作を一覧する
Atsumi, Tatsuya 著作を一覧する
Amengual, Olga 著作を一覧する
Odani, Toshio 著作を一覧する
Otomo, Kotaro 著作を一覧する
Kato, Masaru 著作を一覧する
Oku, Kenji 著作を一覧する
Kon, Yujiro 著作を一覧する
Horita, Tetsuya 著作を一覧する
Yasuda, Shinsuke 著作を一覧する
Koike, Takao 著作を一覧する
キーワード: Anticardiolipin antibody
antiphospholipid antibodies
antiprothrombin antibody
arterial thrombosis
lupus anticoagulant
obstetric complications
phosphatidylserine dependent
venous thrombosis
発行日: 2012年12月
出版者: SAGE Publications
誌名: Lupus
巻: 21
号: 14
開始ページ: 1506
終了ページ: 1514
出版社 DOI: 10.1177/0961203312458469
抄録: Objective: To study the clinical and immunological manifestations of the antiphospholipid syndrome (APS) in Japanese population by a single center registration. Methods: In this retrospective cohort study, 141 consecutive patients with APS, fulfilling the Sydney revised Sapporo criteria for definite APS, who visited to our Autoimmune Clinic from 1988 to 2010 were recruited and followed up. All the patients were interviewed and underwent a general physical examination by qualified rheumatologists on the day of blood sampling. Results: The population comprised 119 woman and 22 men with a mean age at diagnosis of 44 years (range 11-83 years). Seventy patients (49.6%) had primary APS, and 71 (50.4%) had systemic lupus erythematosus. The prevalence of thrombosis was 85.8%, arterial thrombosis was found in 93 patients (66.0%) and venous thrombosis in 46 (32.6%). The most common thrombosis was cerebral infarction [86/141 (61.0%)] followed by deep vein thrombosis [33/141 (23.4%)]. Among 70 pregnant women, 45 (64.3%) had obstetric complications. Lupus anticoagulant was detected in 116 patients (82.3%), anticardiolipin antibodies in 83 (58.9%), anti-β2Glycoprotein I antibodies in 73 (51.8%) and phosphatidylserine-dependent antiprothrombin antibodies in 98 (69.5%). Conclusion: High prevalence of arterial thrombosis was noted in Japanese patients with APS. The profile of heterogeneous and complex clinical manifestations in was substantiated in Japanese patients with APS.
Rights: The final, definitive version of this paper has been published in Lupus, 21(14), Dec. 2012 by SAGE Publications Ltd, All rights reserved. © 2012 SAGE Publications
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/54013
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 藤枝 雄一郎

 

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