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Predominant prevalence of arterial thrombosis in Japanese patients with antiphospholipid syndrome

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Title: Predominant prevalence of arterial thrombosis in Japanese patients with antiphospholipid syndrome
Authors: Fujieda, Yuichiro Browse this author
Atsumi, Tatsuya Browse this author →KAKEN DB
Amengual, Olga Browse this author
Odani, Toshio Browse this author
Otomo, Kotaro Browse this author
Kato, Masaru Browse this author
Oku, Kenji Browse this author
Kon, Yujiro Browse this author
Horita, Tetsuya Browse this author
Yasuda, Shinsuke Browse this author →KAKEN DB
Koike, Takao Browse this author →KAKEN DB
Keywords: Anticardiolipin antibody
antiphospholipid antibodies
antiprothrombin antibody
arterial thrombosis
lupus anticoagulant
obstetric complications
phosphatidylserine dependent
venous thrombosis
Issue Date: Dec-2012
Publisher: SAGE Publications
Journal Title: Lupus
Volume: 21
Issue: 14
Start Page: 1506
End Page: 1514
Publisher DOI: 10.1177/0961203312458469
PMID: 22936124
Abstract: Objective: To study the clinical and immunological manifestations of the antiphospholipid syndrome (APS) in Japanese population by a single center registration. Methods: In this retrospective cohort study, 141 consecutive patients with APS, fulfilling the Sydney revised Sapporo criteria for definite APS, who visited to our Autoimmune Clinic from 1988 to 2010 were recruited and followed up. All the patients were interviewed and underwent a general physical examination by qualified rheumatologists on the day of blood sampling. Results: The population comprised 119 woman and 22 men with a mean age at diagnosis of 44 years (range 11-83 years). Seventy patients (49.6%) had primary APS, and 71 (50.4%) had systemic lupus erythematosus. The prevalence of thrombosis was 85.8%, arterial thrombosis was found in 93 patients (66.0%) and venous thrombosis in 46 (32.6%). The most common thrombosis was cerebral infarction [86/141 (61.0%)] followed by deep vein thrombosis [33/141 (23.4%)]. Among 70 pregnant women, 45 (64.3%) had obstetric complications. Lupus anticoagulant was detected in 116 patients (82.3%), anticardiolipin antibodies in 83 (58.9%), anti-β2Glycoprotein I antibodies in 73 (51.8%) and phosphatidylserine-dependent antiprothrombin antibodies in 98 (69.5%). Conclusion: High prevalence of arterial thrombosis was noted in Japanese patients with APS. The profile of heterogeneous and complex clinical manifestations in was substantiated in Japanese patients with APS.
Rights: The final, definitive version of this paper has been published in Lupus, 21(14), Dec. 2012 by SAGE Publications Ltd, All rights reserved. © 2012 SAGE Publications
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 藤枝 雄一郎

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