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PTHrP promotes malignancy of human oral cancer cell downstream of the EGFR signaling

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Title: PTHrP promotes malignancy of human oral cancer cell downstream of the EGFR signaling
Authors: Yamada, Tamaki Browse this author
Tsuda, Masumi Browse this author →KAKEN DB
Ohba, Yusuke Browse this author →KAKEN DB
Kawaguchi, Hideaki Browse this author →KAKEN DB
Totsuka, Yasunori Browse this author →KAKEN DB
Shindoh, Masanobu Browse this author →KAKEN DB
Keywords: PTHrP
RNA interference
Oral cancer
Issue Date: 11-Apr-2008
Publisher: Elsevier
Journal Title: Biochemical and Biophysical Research Communications
Volume: 368
Issue: 3
Start Page: 575
End Page: 581
Publisher DOI: 10.1016/j.bbrc.2008.01.121
PMID: 18261460
Abstract: Parathyroid hormone-related protein (PTHrP) is detected in many aggressive tumors and involved in malignant conversion; however, the underlying mechanism remains obscure. Here, we identified PTHrP as a mediator of epidermal growth factor receptor (EGFR) signaling to promote the malignancies of oral cancers. PTHrP mRNA was abundantly expressed in most of the quiescent oral cancer cells, and was significantly upregulated by EGF stimulation via ERK and p38 MAPK. PTHrP silencing by RNA interference, as well as EGFR inhibitor AG1478 treatment, significantly suppressed cell proliferation, migration, and invasiveness. Furthermore, combined treatment of AG1478 and PTHrP knockdown achieved synergistic inhibition of malignant phenotypes. Recombinant PTHrP substantially promoted cell motility, and rescued the inhibition by PTHrP knockdown, suggesting the paracrine/autocrine function of PTHrP. These data indicate that PTHrP contributes to the malignancy of oral cancers downstream of EGFR signaling, and may thus provide a therapeutic target for oral cancer.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大場 雄介

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