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Viral envelope protein glycosylation is a molecular determinant of the neuroinvasiveness of the New York strain of West Nile virus

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Title: Viral envelope protein glycosylation is a molecular determinant of the neuroinvasiveness of the New York strain of West Nile virus
Authors: Shirato, Kazuya Browse this author
Miyoshi, Hirotsugu Browse this author
Goto, Akiko Browse this author
Ako, Yoshihiko Browse this author
Ueki, Tomotaka Browse this author
Kariwa, Hiroaki Browse this author →KAKEN DB
Takashima, Ikuo7 Browse this author →KAKEN DB
Authors(alt): 高島, 郁夫7
Issue Date: 2004
Publisher: Society for General Microbiology
Journal Title: Journal of General Virology
Volume: 85
Start Page: 3637
End Page: 3645
Publisher DOI: 10.1099/vir.0.80247-0
PMID: 15557236
Abstract: Two New York (NY) strains of the West Nile (WN) virus were plaque-purified and four variants that had different amino acid sequences at the N-linked glycosylation site in the envelope (E) protein sequence were isolated. The E protein was glycosylated in only two of these strain variants. To determine the relationship between E protein glycosylation and pathogenicity of the WN virus, 6-week-old mice were infected subcutaneously with these variants. Mice infected with viruses that carried the glycosylated E protein developed lethal infection, whereas mice infected with viruses that carried the non-glycosylated E protein showed low mortality. In contrast, intracerebral infection of mice with viruses carrying either the glycosylated or non-glycosylated forms of the E protein resulted in lethal infection. These results suggested that E protein glycosylation is a molecular determinant of neuroinvasiveness in the NY strains of WN virus.
Type: article
URI: http://hdl.handle.net/2115/5569
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高島 郁夫

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