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Utilization of Acidic α-Amino Acids as Acyl Donors: An Effective Stereo-Controllable Synthesis of Aryl-Keto α-Amino Acids and Their Derivatives
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Title: | Utilization of Acidic α-Amino Acids as Acyl Donors: An Effective Stereo-Controllable Synthesis of Aryl-Keto α-Amino Acids and Their Derivatives |
Authors: | Wang, Lei Browse this author | Murai, Yuta Browse this author | Yoshida, Takuma Browse this author | Okamoto, Masashi Browse this author | Tachrim, Zetryana Browse this author | Hashidoko, Yasuyuki Browse this author →KAKEN DB | Hashimoto, Makoto Browse this author →KAKEN DB |
Keywords: | aryl-keto α-amino acid | Friedel-Crafts acylation | Lewis acid | triflic acid |
Issue Date: | May-2014 |
Publisher: | MDPI |
Journal Title: | Molecules |
Volume: | 19 |
Issue: | 5 |
Start Page: | 6349 |
End Page: | 6367 |
Publisher DOI: | 10.3390/molecules19056349 |
Abstract: | Aryl-keto-containing α-amino acids are of great importance in organic chemistry and biochemistry. They are valuable intermediates for the construction of hydroxyl α-amino acids, nonproteinogenic α-amino acids, as well as other biofunctional components. Friedel-Crafts acylation is an effective method to prepare aryl-keto derivatives. In this review, we summarize the preparation of aryl-keto containing α-amino acids by Friedel-Crafts acylation using acidic α-amino acids as acyl-donors and Lewis acids or Brönsted acids as catalysts. |
Rights: | http://creativecommons.org/licenses/by/3.0/ |
Type: | article |
URI: | http://hdl.handle.net/2115/55774 |
Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 橋本 誠
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