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Functional relevance of 'excitatory' GABA actions in cortical interneurons : a dynamical systems approach

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Title: Functional relevance of 'excitatory' GABA actions in cortical interneurons : a dynamical systems approach
Authors: Fujii, Hiroshi Browse this author
Aihara, Kazuyuki Browse this author
Tsuda, Ichito3 Browse this author →KAKEN DB
Authors(alt): 津田, 一郎3
Keywords: Attractor ruin
chaotic itinerancy
Milnor attractor
GABAergic interneuron
activity-dependent excitatory GABA action
Issue Date: Jun-2004
Publisher: Imperial College Press
Journal Title: Journal of Integrative Neuroscience
Volume: 3
Issue: 2
Start Page: 183
End Page: 205
Publisher DOI: 10.1142/S0219635204000506
Abstract: The non-classical, but frequently reported behavior of GABA[A] receptor-mediated excitation in mature CNS has long been regarded as a puzzle. We theorize that the function of cortical GABAergic interneurons, which might constitute a subsystem of brain's GABA interneurons, is their ability of switching from inhibitory action to excitatory action depending on the level of spatio-temporal activity in progress. From the perspective of a dynamical systems approach, such "excitatory" GABAergic responses may serve to temporarily invoke attractor-like memories when extensively activated by, for example, top-down signals as category information or attention, while an ongoing background state of GABA changes its action to inhibition, returning the dynamical nature of the memory structure back to attractor ruins.
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Rights: Copyright (c) 2004 Imperial College Press. The original publication is available at
Type: article (author version)
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 津田 一郎

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