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Functional relevance of 'excitatory' GABA actions in cortical interneurons : a dynamical systems approach
| Title: | Functional relevance of 'excitatory' GABA actions in cortical interneurons : a dynamical systems approach |
| Authors: | Fujii, Hiroshi Browse this author | | Aihara, Kazuyuki Browse this author | | Tsuda, Ichito3 Browse this author →KAKEN DB |
| Authors(alt): | 津田, 一郎3 |
| Keywords: | Attractor ruin | | chaotic itinerancy | | Milnor attractor | | GABAergic interneuron | | activity-dependent excitatory GABA action |
| Issue Date: | Jun-2004 |
| Publisher: | Imperial College Press |
| Journal Title: | Journal of Integrative Neuroscience |
| Volume: | 3 |
| Issue: | 2 |
| Start Page: | 183 |
| End Page: | 205 |
| Publisher DOI: | 10.1142/S0219635204000506 |
| Abstract: | The non-classical, but frequently reported behavior of GABA[A] receptor-mediated excitation in mature CNS has long been regarded as a puzzle. We theorize that the function of cortical GABAergic interneurons, which might constitute a subsystem of brain's GABA interneurons, is their ability of switching from inhibitory action to excitatory action depending on the level of spatio-temporal activity in progress. From the perspective of a dynamical systems approach, such "excitatory" GABAergic responses may serve to temporarily invoke attractor-like memories when extensively activated by, for example, top-down signals as category information or attention, while an ongoing background state of GABA changes its action to inhibition, returning the dynamical nature of the memory structure back to attractor ruins. |
| Description URI: | http://www.worldscinet.com/jin/jin.shtml |
| Rights: | Copyright (c) 2004 Imperial College Press. The original publication is available at www.worldscinet.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/588 |
| Appears in Collections: | 理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 津田 一郎
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