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Functional relevance of 'excitatory' GABA actions in cortical interneurons : a dynamical systems approach

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タイトル: Functional relevance of 'excitatory' GABA actions in cortical interneurons : a dynamical systems approach
著者: Fujii, Hiroshi 著作を一覧する
Aihara, Kazuyuki 著作を一覧する
Tsuda, Ichito 著作を一覧する
キーワード: Attractor ruin
chaotic itinerancy
Milnor attractor
GABAergic interneuron
activity-dependent excitatory GABA action
発行日: 2004年 6月
出版者: Imperial College Press
誌名: Journal of Integrative Neuroscience
巻: 3
号: 2
開始ページ: 183
終了ページ: 205
出版社 DOI: 10.1142/S0219635204000506
抄録: The non-classical, but frequently reported behavior of GABA[A] receptor-mediated excitation in mature CNS has long been regarded as a puzzle. We theorize that the function of cortical GABAergic interneurons, which might constitute a subsystem of brain's GABA interneurons, is their ability of switching from inhibitory action to excitatory action depending on the level of spatio-temporal activity in progress. From the perspective of a dynamical systems approach, such "excitatory" GABAergic responses may serve to temporarily invoke attractor-like memories when extensively activated by, for example, top-down signals as category information or attention, while an ongoing background state of GABA changes its action to inhibition, returning the dynamical nature of the memory structure back to attractor ruins.
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Rights: Copyright (c) 2004 Imperial College Press. The original publication is available at
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 津田 一郎


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