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Volume 63 Number 2 >

Identification of multiple genetic loci in the mouse controlling immobility time in the tail suspension and forced swimming tests

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Title: Identification of multiple genetic loci in the mouse controlling immobility time in the tail suspension and forced swimming tests
Authors: Abou-Elnaga, Ahmed F. Browse this author
Torigoe, Daisuke Browse this author
Fouda, Mohamed M. Browse this author
Darwish, Ragab A. Browse this author
Abou-Ismail, Usama A. Browse this author
Morimatsu, Masami Browse this author →KAKEN DB
Agui, Takashi Browse this author →KAKEN DB
Keywords: depression
tail suspension test
forced swimming test
QTL analysis
Issue Date: May-2015
Publisher: Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 63
Issue: 2
Start Page: 53
End Page: 62
Abstract: Depression is one of the most famous psychiatric disorders in humans in all over the countries and considered a complex neurobehavioral trait and difficult to identify causal genes. Tail suspension test (TST) and forced swimming test (FST) are widely used for assessing depression-like behavior and antidepressant activity in mice. A variety of antidepressant agents are known to reduce immobility time in both TST and FST. To identify genetic determinants of immobility duration in both tests, we analyzed 101 F2 mice from an intercross between C57BL/6 and DBA/2 strains. Quantitative trait locus (QTL) mapping using 106 microsatellite markers revealed three loci (two significant and one suggestive) and five suggestive loci controlling immobility time in the TST and FST, respectively. Results of QTL analysis suggest a broad description of the genetic architecture underlying depression, providing underpinnings for identifying novel molecular targets for antidepressants to clear the complex genetic mechanisms of depressive disorders.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 63 Number 2

Submitter: 獣医学部図書室

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