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Acute Zonal Occult Outer Retinopathy in Japanese Patients : Clinical Features, Visual Function, and Factors Affecting Visual Function

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Title: Acute Zonal Occult Outer Retinopathy in Japanese Patients : Clinical Features, Visual Function, and Factors Affecting Visual Function
Authors: Saito, Saho Browse this author
Saito, Wataru Browse this author
Saito, Michiyuki Browse this author
Hashimoto, Yuki Browse this author
Mori, Shohei Browse this author
Noda, Kousuke Browse this author →KAKEN DB
Namba, Kenichi Browse this author →KAKEN DB
Ishida, Susumu Browse this author →KAKEN DB
Issue Date: 28-Apr-2015
Publisher: PLOS
Journal Title: PLOS ONE
Volume: 10
Issue: 4
Start Page: e0125133
Publisher DOI: 10.1371/journal.pone.0125133
Abstract: Purpose To evaluate the clinical features and investigate their relationship with visual function in Japanese patients with acute zonal occult outer retinopathy (AZOOR). Methods Fifty-two eyes of 38 Japanese AZOOR patients (31 female and 7 male patients; mean age at first visit, 35.0 years; median follow-up duration, 31 months) were retrospectively collected: 31 untreated eyes with good visual acuity and 21 systemic corticosteroid-treated eyes with progressive visual acuity loss. Variables affecting the logMAR values of best-corrected visual acuity (BCVA) and the mean deviation (MD) on Humphrey perimetry at initial and final visits were examined using multiple stepwise linear regression analysis. Results In untreated eyes, the mean MD at the final visit was significantly higher than that at the initial visit (P = 0.00002). In corticosteroid-treated eyes, the logMAR BCVA and MD at the final visit were significantly better than the initial values (P = 0.007 and P = 0.02, respectively). The final logMAR BCVA was 0.0 or less in 85% of patients. Variables affecting initial visual function were moderate anterior vitreous cells, myopia severity, and a-wave amplitudes on electroretinography; factors affecting final visual function were the initial MD values, female sex, moderate anterior vitreous cells, and retinal atrophy. Conclusions Our data indicated that visual functions in enrolled patients significantly improved spontaneously or after systemic corticosteroids therapy, suggesting that Japanese patients with AZOOR have good visual outcomes during the follow-up period of this study. Furthermore, initial visual field defects, gender, anterior vitreous cells, and retinal atrophy affected final visual functions in these patients.
Rights: http://creativecommons.org/licenses/by/4.0
Type: article
URI: http://hdl.handle.net/2115/59432
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 齋藤 航

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