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Rapid Evaluation of Fibrinogen Levels Using the CG02N Whole Blood Coagulation Analyzer
Title: | Rapid Evaluation of Fibrinogen Levels Using the CG02N Whole Blood Coagulation Analyzer |
Authors: | Hayakawa, Mineji Browse this author →KAKEN DB | Gando, Satoshi Browse this author →KAKEN DB | Ono, Yuichi Browse this author | Mizugaki, Asumi Browse this author | Katabami, Kenichi Browse this author | Maekawa, Kunihiko Browse this author | Miyamoto, Daisuke Browse this author | Wada, Takeshi Browse this author | Yanagida, Yuichiro Browse this author | Sawamura, Atsushi Browse this author →KAKEN DB |
Keywords: | fibrinogen | point-of-care | coagulopathy | massive transfusion |
Issue Date: | Apr-2015 |
Publisher: | Thieme |
Journal Title: | Seminars in thrombosis and hemostasis |
Volume: | 41 |
Issue: | 3 |
Start Page: | 267 |
End Page: | 271 |
Publisher DOI: | 10.1055/s-0035-1547372 |
PMID: | 25839869 |
Abstract: | Rapid evaluation of fibrinogen (Fbg) levels is essential for maintaining homeostasis in patients with massive bleeding during severe trauma and major surgery. This study evaluated the accuracy of fibrinogen levels measured by the CG02N whole blood coagulation analyzer (A&T Corporation, Kanagawa, Japan) using heparinized blood drawn for blood gas analysis (whole blood-Fbg). A total of 100 matched pairs of heparinized blood samples and citrated blood samples were simultaneously collected from patients in the intensive care unit. Whole blood-Fbg results were compared with those of citrated plasma (standard-Fbg). The whole blood coagulation analyzer measured fibrinogen levels within 2 minutes. Strong correlations between standard-Fbg and whole blood-Fbg were observed (ρ = 0.91, p < 0.001). Error grid analysis showed that 88% of the values were clinically acceptable, and 12% were in a range with possible effects on clinical decision-making; none were in a clinically dangerous range without appropriate treatment. Using a fibrinogen cutoff value of 1.5 g/L for standard-Fbg, the area under the receiver operating characteristic curve of whole blood-Fbg was 0.980 (95% confidence interval 0.951-1.000, p < 0.001). The whole blood coagulation analyzer can rapidly measure fibrinogen levels in heparinized blood and could be useful in critical care settings where excessive bleeding is a concern. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/61135 |
Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 早川 峰司
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