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Rapid Evaluation of Fibrinogen Levels Using the CG02N Whole Blood Coagulation Analyzer

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Title: Rapid Evaluation of Fibrinogen Levels Using the CG02N Whole Blood Coagulation Analyzer
Authors: Hayakawa, Mineji Browse this author →KAKEN DB
Gando, Satoshi Browse this author →KAKEN DB
Ono, Yuichi Browse this author
Mizugaki, Asumi Browse this author
Katabami, Kenichi Browse this author
Maekawa, Kunihiko Browse this author
Miyamoto, Daisuke Browse this author
Wada, Takeshi Browse this author
Yanagida, Yuichiro Browse this author
Sawamura, Atsushi Browse this author →KAKEN DB
Keywords: fibrinogen
massive transfusion
Issue Date: Apr-2015
Publisher: Thieme
Journal Title: Seminars in thrombosis and hemostasis
Volume: 41
Issue: 3
Start Page: 267
End Page: 271
Publisher DOI: 10.1055/s-0035-1547372
PMID: 25839869
Abstract: Rapid evaluation of fibrinogen (Fbg) levels is essential for maintaining homeostasis in patients with massive bleeding during severe trauma and major surgery. This study evaluated the accuracy of fibrinogen levels measured by the CG02N whole blood coagulation analyzer (A&T Corporation, Kanagawa, Japan) using heparinized blood drawn for blood gas analysis (whole blood-Fbg). A total of 100 matched pairs of heparinized blood samples and citrated blood samples were simultaneously collected from patients in the intensive care unit. Whole blood-Fbg results were compared with those of citrated plasma (standard-Fbg). The whole blood coagulation analyzer measured fibrinogen levels within 2 minutes. Strong correlations between standard-Fbg and whole blood-Fbg were observed (ρ = 0.91, p < 0.001). Error grid analysis showed that 88% of the values were clinically acceptable, and 12% were in a range with possible effects on clinical decision-making; none were in a clinically dangerous range without appropriate treatment. Using a fibrinogen cutoff value of 1.5 g/L for standard-Fbg, the area under the receiver operating characteristic curve of whole blood-Fbg was 0.980 (95% confidence interval 0.951-1.000, p < 0.001). The whole blood coagulation analyzer can rapidly measure fibrinogen levels in heparinized blood and could be useful in critical care settings where excessive bleeding is a concern.
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 早川 峰司

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