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Zincmethylphyrins and coproporphyrins, novel growth factors released by Sphingopyxis sp., enable laboratory cultivation of previously uncultured Leucobacter sp through interspecies mutualism

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Title: Zincmethylphyrins and coproporphyrins, novel growth factors released by Sphingopyxis sp., enable laboratory cultivation of previously uncultured Leucobacter sp through interspecies mutualism
Authors: Bhuiyan, Mohammad Nazrul Islam Browse this author
Takai, Ryogo Browse this author
Mitsuhashi, Shinya Browse this author
Shigetomi, Kengo Browse this author
Tanaka, Yasuhiro Browse this author
Kamagata, Yoichi Browse this author
Ubukata, Makoto Browse this author →KAKEN DB
Issue Date: 26-Aug-2015
Publisher: 日本抗生物質学術協議会
Journal Title: Journal of antibiotics
Volume: 69
Issue: 2
Start Page: 97
End Page: 103
Publisher DOI: 10.1038/ja.2015.87
PMID: 26306814
Abstract: We have identified coproporphyrins including structurally new zincmethylphyrins I and III as growth factors A-F for the previously uncultured bacterial strain, Leucobacter sp. ASN212, from a supernatant of 210 l of Sphingopyxis sp. GF9 culture. Growth factors A-F induced significant growth of strain ASN212 at the concentrations of picomolar to nanomolar which would otherwise be unculturable in liquid medium or on agar plate. More interestingly, we found that the growth factors functioned as self-toxic compounds for the growth-factor producing strain GF9 at the picomolar to nanomolar levels. As a variety of bacteria could potentially produce coproporphyrins, our findings suggest that these compounds function as a novel class of signal molecules across a boundary at phylum level in the complex bacterial communities.
Type: article (author version)
URI: http://hdl.handle.net/2115/61410
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 生方 信

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