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Left–right asymmetric cell intercalation drives directional collective cell movement in epithelial morphogenesis

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Title: Left–right asymmetric cell intercalation drives directional collective cell movement in epithelial morphogenesis
Authors: Sato, Katsuhiko Browse this author →KAKEN DB
Hiraiwa, Tetsuya Browse this author
Maekawa, Emi Browse this author
Isomura, Ayako Browse this author
Shibata, Tatsuo Browse this author →KAKEN DB
Kuranaga, Erina Browse this author →KAKEN DB
Issue Date: 10-Dec-2015
Publisher: Nature Publishing Group
Journal Title: Nature Communications
Volume: 6
Start Page: 10074
Publisher DOI: 10.1038/ncomms10074
Abstract: Morphogenetic epithelial movement occurs during embryogenesis and drives complex tissue formation. However, how epithelial cells coordinate their unidirectional movement while maintaining epithelial integrity is unclear. Here we propose a novel mechanism for collective epithelial cell movement based on Drosophila genitalia rotation, in which epithelial tissue rotates clockwise around the genitalia. We found that this cell movement occurs autonomously and requires myosin II. The moving cells exhibit repeated left–right-biased junction remodelling, while maintaining adhesion with their neighbours, in association with a polarized myosin II distribution. Reducing myosinID, known to cause counter-clockwise epithelial-tissue movement, reverses the myosin II distribution. Numerical simulations revealed that a left–right asymmetry in cell intercalation is sufficient to induce unidirectional cellular movement. The cellular movement direction is also associated with planar cell-shape chirality. These findings support a model in which left–right asymmetric cell intercalation within an epithelial sheet drives collective cellular movement in the same direction.
Type: article
Appears in Collections:電子科学研究所 (Research Institute for Electronic Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐藤 勝彦

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