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Laboratory and clinical features of abnormal macroenzymes found in human sera

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Title: Laboratory and clinical features of abnormal macroenzymes found in human sera
Authors: Moriyama, Takanori Browse this author →KAKEN DB
Tamura, Shogo Browse this author
Nakano, Keiichi Browse this author
Otsuka, Kohei Browse this author
Shigemura, Masahiko Browse this author
Honma, Naoyuki Browse this author
Keywords: Macroenzyme
Macro aspartate aminotransferase (AST)
Macroamylase
Macro lactate dehydrogenase (LD)
Macro creatine kinase (CK)
Issue Date: Jun-2015
Publisher: Elsevier
Journal Title: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Volume: 1854
Issue: 6
Start Page: 658
End Page: 667
Publisher DOI: 10.1016/j.bbapap.2014.10.015
PMID: 25545221
Abstract: We report the analysis of unusual macroenzymes, performed in our laboratory, and review the relevant literature. In particular, we focused on macro AST, macroamylase, macro LD and macro CK. Macroenzymes are seen in healthy subjects, but can also be related to disease; thus, accurate detection is useful in day-to-day clinical practice. The macroenzyme is thought to be a specific antigen–antibody complex from the following findings: (1) the complex could be dissociated under acidic pH levels; (2) binding specificity of immunoglobulin in the complex was observed; (3) the binding site of immunoglobulin in the complex was Fab portion; and (4) the maternal IgG involved with macroenzyme was transferred to her children. This article is part of a Special Issue entitled: Medical Proteomics.
Rights: ©2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/62307
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 森山 隆則

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