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Hokkaido University Collection of Scholarly and Academic Papers >
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Laboratory and clinical features of abnormal macroenzymes found in human sera
This item is licensed under:Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
| Title: | Laboratory and clinical features of abnormal macroenzymes found in human sera |
| Authors: | Moriyama, Takanori Browse this author →KAKEN DB | | Tamura, Shogo Browse this author | | Nakano, Keiichi Browse this author | | Otsuka, Kohei Browse this author | | Shigemura, Masahiko Browse this author | | Honma, Naoyuki Browse this author |
| Keywords: | Macroenzyme | | Macro aspartate aminotransferase (AST) | | Macroamylase | | Macro lactate dehydrogenase (LD) | | Macro creatine kinase (CK) |
| Issue Date: | Jun-2015 |
| Publisher: | Elsevier |
| Journal Title: | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics |
| Volume: | 1854 |
| Issue: | 6 |
| Start Page: | 658 |
| End Page: | 667 |
| Publisher DOI: | 10.1016/j.bbapap.2014.10.015 |
| PMID: | 25545221 |
| Abstract: | We report the analysis of unusual macroenzymes, performed in our laboratory, and review the relevant literature. In particular, we focused on macro AST, macroamylase, macro LD and macro CK. Macroenzymes are seen in healthy subjects, but can also be related to disease; thus, accurate detection is useful in day-to-day clinical practice. The macroenzyme is thought to be a specific antigen–antibody complex from the following findings: (1) the complex could be dissociated under acidic pH levels; (2) binding specificity of immunoglobulin in the complex was observed; (3) the binding site of immunoglobulin in the complex was Fab portion; and (4) the maternal IgG involved with macroenzyme was transferred to her children. This article is part of a Special Issue entitled: Medical Proteomics. |
| Rights: | ©2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/62307 |
| Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 森山 隆則
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