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Myeloid molecular characteristics of human γδ T cells support their acquisition of tumor antigen-presenting capacity
| Title: | Myeloid molecular characteristics of human γδ T cells support their acquisition of tumor antigen-presenting capacity |
| Authors: | Muto, Masato Browse this author | | Baghdadi, Muhammad Browse this author | | Maekawa, Ryuji Browse this author | | Wada, Haruka Browse this author →KAKEN DB | | Seino, Ken-ichiro Browse this author →KAKEN DB |
| Keywords: | γδ T cells | | Zoledronate | | Antigen-presenting capacity | | CD36 | | C/EBPα | | Myeloid |
| Issue Date: | Aug-2015 |
| Publisher: | Springer |
| Journal Title: | Cancer immunology, immunotherapy |
| Volume: | 64 |
| Issue: | 8 |
| Start Page: | 941 |
| End Page: | 949 |
| Publisher DOI: | 10.1007/s00262-015-1700-x |
| PMID: | 25904200 |
| Abstract: | Human T cells expressing γδ T cell receptor have a potential to show antigen-presenting cell-like phenotype and function upon their activation. However, the mechanisms that underlie the alterations in human γδ T cells remain largely unclear. In this study, we have investigated the molecular characteristics of human γδ T cells related to their acquisition of antigen-presenting capacity in comparison with activated αβ T cells. We found that activated γδ but not αβ T cells upregulated cell surface expression of a scavenger receptor, CD36, which seemed to be mediated by signaling through mitogen-activated protein kinase and/or NF-κB pathways. Confocal microscopical analysis revealed that activated γδ T cells can phagocytose protein antigens. Activated γδ T cells could induce tumor antigen-specific CD8+ T cells using both apoptotic and live tumor cells as antigen resources. Furthermore, we detected that C/EBPα, a critical transcription factor for the development of myeloid-lineage cells, is expressed much higher in γδ T cells than in αβ T cells. These results unveiled the molecular mechanisms for the elicitation of antigen-presenting functions in γδ T cells and would also help designing new approaches for γδ T cell-mediated human cancer immunotherapy. |
| Rights: | The final publication is available at Springer via http://dx.doi.org/10.1007/s00262-015-1700-x |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/62586 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 清野 研一郎
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