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Stabilization of intracellular trafficking and metabolism of amyloid β-protein precursor and Alcadein β by apolipoprotein E

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タイトル: Stabilization of intracellular trafficking and metabolism of amyloid β-protein precursor and Alcadein β by apolipoprotein E
著者: Kimura, Ayano 著作を一覧する
Hata, Saori 著作を一覧する
Suzuki, Toshiharu 著作を一覧する
キーワード: Amyloid beta-protein precursor
Alcadein
Apolipoprotein E
Alzheimer's disease
発行日: 2015年
出版者: Wiley
誌名: FEBS Letters
巻: 589
号: 18
開始ページ: 2394
終了ページ: 2400
出版社 DOI: 10.1016/j.febslet.2015.07.017
抄録: Intracellular metabolism of amyloid beta-protein precursor (APP) is important for the pathogenesis of Alzheimer's disease (AD). Alcadeins (Alc alpha, Alc beta, and Alc gamma) are neural membrane proteins similar to APP in their localization, metabolism, and cellular function. Isoform epsilon 4 of apolipoprotein E (ApoE) is a major risk factor for AD. We found that ApoE expression attenuated intracellular trafficking of APP and Alc beta, resulting in metabolic stabilization of both proteins. By contrast, Alc alpha intracellular proteolysis was facilitated by ApoE expression, which was not due to an increase in the primary cleavage of Alc alpha. This difference may result from binding of ApoE to membrane proteins. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Rights: This is the peer reviewed version of the following article: Kimura Ayano, Hata Saori and Suzuki Toshiharu(2015), Stabilization of intracellular trafficking and metabolism of amyloid β-protein precursor and Alcadein β by apolipoprotein E, FEBS Letters, 589, which has been published in final form at http://dx.doi.org/10.1016/j.febslet.2015.07.017. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/62695
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 鈴木 利治

 

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