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Stabilization of intracellular trafficking and metabolism of amyloid β-protein precursor and Alcadein β by apolipoprotein E

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Title: Stabilization of intracellular trafficking and metabolism of amyloid β-protein precursor and Alcadein β by apolipoprotein E
Authors: Kimura, Ayano Browse this author
Hata, Saori Browse this author →KAKEN DB
Suzuki, Toshiharu Browse this author →KAKEN DB
Keywords: Amyloid beta-protein precursor
Alcadein
Apolipoprotein E
Alzheimer's disease
Issue Date: 2015
Publisher: Wiley
Journal Title: FEBS Letters
Volume: 589
Issue: 18
Start Page: 2394
End Page: 2400
Publisher DOI: 10.1016/j.febslet.2015.07.017
PMID: 26213366
Abstract: Intracellular metabolism of amyloid beta-protein precursor (APP) is important for the pathogenesis of Alzheimer's disease (AD). Alcadeins (Alc alpha, Alc beta, and Alc gamma) are neural membrane proteins similar to APP in their localization, metabolism, and cellular function. Isoform epsilon 4 of apolipoprotein E (ApoE) is a major risk factor for AD. We found that ApoE expression attenuated intracellular trafficking of APP and Alc beta, resulting in metabolic stabilization of both proteins. By contrast, Alc alpha intracellular proteolysis was facilitated by ApoE expression, which was not due to an increase in the primary cleavage of Alc alpha. This difference may result from binding of ApoE to membrane proteins.
Rights: This is the peer reviewed version of the following article: Kimura Ayano, Hata Saori and Suzuki Toshiharu(2015), Stabilization of intracellular trafficking and metabolism of amyloid β-protein precursor and Alcadein β by apolipoprotein E, FEBS Letters, 589, which has been published in final form at http://dx.doi.org/10.1016/j.febslet.2015.07.017. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/62695
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 鈴木 利治

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