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Spatial dynamics of action potentials estimated by dendritic Ca2+ signals in insect projection neurons
| Title: | Spatial dynamics of action potentials estimated by dendritic Ca2+ signals in insect projection neurons |
| Authors: | Ogawa, Hiroto Browse this author | | Mitani, Ruriko Browse this author |
| Keywords: | Calcium imaging | | Dendrite | | Insect neuron | | Laterality | | Spike initiation zone | | Spike propagation |
| Issue Date: | 2015 |
| Journal Title: | Biochemical and Biophysical Research Communications |
| Volume: | 467 |
| Issue: | 2 |
| Start Page: | 185 |
| End Page: | 190 |
| Publisher DOI: | 10.1016/j.bbrc.2015.10.021 |
| PMID: | 26456645 |
| Abstract: | The spatial dynamics of action potentials, including their propagation and the location of spike initiation zone (SIZ), are crucial for the computation of a single neuron. Compared with mammalian central neurons, the spike dynamics of invertebrate neurons remain relatively unknown. Thus, we examined the spike dynamics based on single spike-induced Ca2+ signals in the dendrites of cricket mechanosensory projection neurons, known as giant interneurons (GIs). The Ca2+ transients induced by a synaptically evoked single spike were larger than those induced by an antidromic spike, whereas subthreshold synaptic potentials caused no elevation of Ca2+. These results indicate that synaptic activity enhances the dendritic Ca2+ influx through voltage-gated Ca2+ channels. Stimulation of the presynaptic sensory afferents ipsilateral to the recording site evoked a dendritic spike with higher amplitude than contralateral stimulation, thereby suggesting that alteration of the spike waveform resulted in synaptic enhancement of the dendritic Ca2+ transients. The SIZ estimated from the spatial distribution of the difference in the Ca2+ amplitude was distributed throughout the right and left dendritic branches across the primary neurite connecting them in GIs. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/62889 |
| Appears in Collections: | 理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 小川 宏人
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