HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Faculty of Pharmaceutical Sciences >
Peer-reviewed Journal Articles, etc >

Involvement of Monocarboxylate Transporter 4 Expression in Statin-Induced Cytotoxicity

Creative Commons License

Files in This Item:
manuscript.pdf327.46 kBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/64942

Title: Involvement of Monocarboxylate Transporter 4 Expression in Statin-Induced Cytotoxicity
Authors: Kikutani, Yurika Browse this author
Kobayashi, Masaki Browse this author →KAKEN DB
Konishi, Toru Browse this author
Sasaki, Shotaro Browse this author
Narumi, Katsuya Browse this author
Furugen, Ayako Browse this author
Takahashi, Natsuko Browse this author →KAKEN DB
Iseki, Ken Browse this author →KAKEN DB
Keywords: monocarboxylate transporter 4
statin
cytotoxicity
Issue Date: Apr-2016
Publisher: Elsevier
Journal Title: Journal of Pharmaceutical Sciences
Volume: 105
Issue: 4
Start Page: 1544
End Page: 1549
Publisher DOI: 10.1016/j.xphs.2016.01.014
PMID: 26935883
Abstract: Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are the most widely used cholesterol-lowering agents for prevention of obstructive cardiovascular events. However, statins can cause a variety of skeletal muscle problems, and exercise leads to an increase in statin-induced muscle injury. Exercise induces the protein content of monocarboxylate transporter 4 (MCT4), which is expressed strongly in skeletal muscle and is thought to play a major role in the transport of metabolically important monocarboxylates such as L-lactate. We previously reported that alpha-cyano-4-hydroxycinnamate, an MCT4 inhibitor, increased the inhibition of growth of RD cells, a prototypic embryonal rhabdomyosarcoma cell line (an RD cell line), as a model of in vitro skeletal muscle, induced by a statin. However, it is unclear whether statin-induced RD cell cytotoxicity is associated with MCT4 expression. We, therefore, examined the relationship between statin-induced cytotoxicity and MCT4 expression in RD cells. Atorvastatin reduced the number of viable cells and upregulated MCT4, but not MCT1, mRNA level in a concentration-dependent manner. MCT4 knockdown suppressed atorvastatin-, simvastatin-, and fluvastatin-induced reduction of cell viability and apoptosis compared with negative controletreated cells. In this study, we demonstrated that MCT4 expression is associated with statin-induced cytotoxicity. (C) 2016 American Pharmacists Association(R). Published by Elsevier Inc. All rights reserved.
Rights: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/64942
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小林 正紀

Export metadata:

OAI-PMH ( junii2 , jpcoar )

MathJax is now OFF:


 

Feedback - Hokkaido University