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Treatment of Vasodilator-resistant Mixed Connective Tissue Disease-associated Pulmonary Arterial Hypertension with Glucocorticoid and Cyclophosphamide
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Title: | Treatment of Vasodilator-resistant Mixed Connective Tissue Disease-associated Pulmonary Arterial Hypertension with Glucocorticoid and Cyclophosphamide |
Authors: | Sugawara, Eri Browse this author | Kato, Masaru Browse this author →KAKEN DB | Hisada, Ryo Browse this author | Oku, Kenji Browse this author | Bohgaki, Toshiyuki Browse this author | Horita, Tetsuya Browse this author →KAKEN DB | Yasuda, Shinsuke Browse this author →KAKEN DB | Atsumi, Tatsuya Browse this author →KAKEN DB |
Keywords: | pulmonary arterial hypertension | mixed connective tissue disease | glucocorticoid | intravenous cyclophosphamide |
Issue Date: | 2017 |
Publisher: | The Japanese Society of Internal Medicine |
Journal Title: | Internal medicine |
Volume: | 56 |
Issue: | 4 |
Start Page: | 445 |
End Page: | 448 |
Publisher DOI: | 10.2169/internalmedicine.56.7668 |
Abstract: | Pulmonary arterial hypertension (PAH) associated with systemic lupus erythematosus (SLE) or mixed connective tissue disease (MTCD), in contrast to other types of PAH, may respond to immunosuppressive therapy. Most PAH cases with an immunosuppressant response were in the early stages of the disease (WHO functional class III or less). The present case was a 34-year-old woman with MCTD-associated PAH (WHO functional class IV) who was resistant to a combination of three vasodilators. Afterwards, she was treated with glucocorticoid and cyclophosphamide. This case suggested the potential benefit of immunosuppressants in patients with severe MCTD-associated PAH. |
Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Type: | article |
URI: | http://hdl.handle.net/2115/65665 |
Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 加藤 将
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