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Treatment of Vasodilator-resistant Mixed Connective Tissue Disease-associated Pulmonary Arterial Hypertension with Glucocorticoid and Cyclophosphamide

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Title: Treatment of Vasodilator-resistant Mixed Connective Tissue Disease-associated Pulmonary Arterial Hypertension with Glucocorticoid and Cyclophosphamide
Authors: Sugawara, Eri Browse this author
Kato, Masaru Browse this author →KAKEN DB
Hisada, Ryo Browse this author
Oku, Kenji Browse this author
Bohgaki, Toshiyuki Browse this author
Horita, Tetsuya Browse this author →KAKEN DB
Yasuda, Shinsuke Browse this author →KAKEN DB
Atsumi, Tatsuya Browse this author →KAKEN DB
Keywords: pulmonary arterial hypertension
mixed connective tissue disease
glucocorticoid
intravenous cyclophosphamide
Issue Date: 2017
Publisher: The Japanese Society of Internal Medicine
Journal Title: Internal medicine
Volume: 56
Issue: 4
Start Page: 445
End Page: 448
Publisher DOI: 10.2169/internalmedicine.56.7668
Abstract: Pulmonary arterial hypertension (PAH) associated with systemic lupus erythematosus (SLE) or mixed connective tissue disease (MTCD), in contrast to other types of PAH, may respond to immunosuppressive therapy. Most PAH cases with an immunosuppressant response were in the early stages of the disease (WHO functional class III or less). The present case was a 34-year-old woman with MCTD-associated PAH (WHO functional class IV) who was resistant to a combination of three vasodilators. Afterwards, she was treated with glucocorticoid and cyclophosphamide. This case suggested the potential benefit of immunosuppressants in patients with severe MCTD-associated PAH.
Rights: https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article
URI: http://hdl.handle.net/2115/65665
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 将

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