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Dynamics of fibrinogen in acute phases of trauma

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Title: Dynamics of fibrinogen in acute phases of trauma
Authors: Hayakawa, Mineji Browse this author →KAKEN DB
Keywords: Coagulopathy
Disseminated intravascular coagulation
Massive bleeding
Issue Date: 2017
Publisher: BioMed Central
Journal Title: Journal of Intensive Care
Volume: 5
Start Page: 3
Publisher DOI: 10.1186/s40560-016-0199-3
Abstract: Fibrinogen is a unique precursor of fibrin and cannot be compensated for by other coagulation factors. If plasma fibrinogen concentrations are insufficient, hemostatic clots cannot be formed with the appropriate firmness. In severe trauma patients, plasma fibrinogen concentrations decrease earlier and more frequently than other coagulation factors, predicting massive bleeding and death. We review the mechanisms of plasma fibrinogen concentration decrease, which include coagulation activation-induced consumption, hyper-fibrino(geno)lysis-induced degradation, and dilution by infusion/transfusion. Understanding the mechanisms of plasma fibrinogen concentration decrease in severe trauma patients is crucial.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 早川 峰司

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