HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Theses >
博士 (医学) >

CD40 Expression in Human Esophageal Squamous Cell Carcinoma Is Associated with Tumor Progression and Lymph Node Metastasis

Files in This Item:
Yoshiyuki_Matsumura.pdf575 kBPDFView/Open
Please use this identifier to cite or link to this item:https://doi.org/10.14943/doctoral.k12531
Related Items in HUSCAP:

Title: CD40 Expression in Human Esophageal Squamous Cell Carcinoma Is Associated with Tumor Progression and Lymph Node Metastasis
Other Titles: 食道扁平上皮癌におけるCD40の発現は腫瘍の進行とリンパ節転移に関係する
Authors: 松村, 祥幸 Browse this author
Keywords: CD40
CD154
CD40 ligand
CD40L
esophageal squamous cell carcinoma
IL6
Issue Date: 23-Mar-2017
Publisher: Hokkaido University
Publisher DOI: 10.21873/anticanres.10991
PMID: 27630283
Abstract: Background: The co-stimulatory molecule cluster of differentiation 40 (CD40) is widely expressed in various types of malignant tumors, but its role remains unclear. The purpose of this study was to investigate the relationship between CD40 expression and clinicopathological variables in patients with esophageal squamous cell carcinoma (ESCC), as well as the function of CD40 expressed on ESCC tumor cells in vitro. Materials and Methods: Tumor specimens of patients who underwent surgical resection for ESCC were immunohistochemically analyzed for CD40 expression. Results: Of the 122 specimens, 45 (37%) were positive for CD40. Significant positive correlation was found between CD40 expression and p-stage (p=0.0011), histopathological grade (p=0.0143), pT-classification (p=0.0011), and pN-classification (p=0.0007). Survival of patients with stage III and IV disease with positive CD40 expression was significantly shorter than that of those with negative expression (log-rank test, p=0.0422). In in vitro analysis, while the addition of recombinant human CD154 did not inhibit growth, it did induce a significant increase in interleukin 6 production in ESCC cell lines. Conclusion: These results suggest that functional expression of CD40 on tumor cells might play an important role in tumor progression and lymph node metastasis in ESCC.
Description: Citation: YOSHIYUKI MATSUMURA, KEI HIRAOKA, KEIDAI ISHIKAWA, YASUHITO SHOJI, TAKEHIRO NOJI, KOJI HONTANI, TOMOO ITOH, TORU NAKAMURA, TAKAHIRO TSUCHIKAWA, TOSHIAKI SHICHINOHE and SATOSHI HIRANO. CD40 Expression in Human Esophageal Squamous Cell Carcinoma Is Associated with Tumor Progression and Lymph Node Metastasis. ANTICANCER RESEARCH 36(9): 4467-4475 (2016). doi:10.21873/anticanres.10991
配架番号:2272
Conffering University: 北海道大学
Degree Report Number: 甲第12531号
Degree Level: 博士
Degree Discipline: 医学
Examination Committee Members: (主査) 教授 秋田 弘俊, 准教授 本間 明宏, 教授 平野 聡
Degree Affiliation: 医学研究科(癌医学専攻)
Type: theses (doctoral)
URI: http://hdl.handle.net/2115/66618
Appears in Collections:課程博士 (Doctorate by way of Advanced Course) > 医学院(Graduate School of Medicine)
学位論文 (Theses) > 博士 (医学)

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 

 - Hokkaido University