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Hepatectomy for Hepatocellular Carcinoma with Bile Duct Tumor Thrombus, Including Cases with Obstructive Jaundice
Title: | Hepatectomy for Hepatocellular Carcinoma with Bile Duct Tumor Thrombus, Including Cases with Obstructive Jaundice |
Other Titles: | HCC with bile duct tumor thrombus |
Authors: | Orimo, Tatsuya Browse this author | Kamiyama, Toshiya Browse this author →KAKEN DB | Yokoo, Hideki Browse this author →KAKEN DB | Wakayama, Kenji Browse this author | Shimada, Shingo Browse this author | Tsuruga, Yosuke Browse this author | Kamachi, Hirofumi Browse this author →KAKEN DB | Taketomi, Akinobu Browse this author →KAKEN DB |
Issue Date: | Aug-2016 |
Publisher: | Springer |
Journal Title: | Annals of surgical oncology |
Volume: | 23 |
Issue: | 8 |
Start Page: | 2627 |
End Page: | 2634 |
Publisher DOI: | 10.1245/s10434-016-5174-7 |
PMID: | 27006124 |
Abstract: | Background: This study aimed to evaluate the short- and long-term outcomes of hepatectomy for hepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT), including cases with obstructive jaundice. Methods: The study reviewed 42 HCC patients with BDTT, including six patients who needed preoperative biliary drainage due to obstructive jaundice, and 732 HCC patients without BDTT. The authors analyzed the impact of BDTT on the surgical outcomes and assessed the outcomes of hepatectomy for patients presenting with obstructive jaundice. Results: The HCC patients with BDTT, almost all with stage 3 or 4 disease, had increased alpha-fetoprotein expression, larger tumors, and more portal vein invasion status. The survival of the HCC patients with BDTT was significantly inferior to that of the patients without BDTT (p = 0.0003). Survival did not differ significantly between the HCC patients with BDTT and those without BDTT when the two groups were matched by stage (p = 0.3366). The HCC patients with BDTT who presented with obstructive jaundice demonstrated outcomes similar to those for the HCC patients with BDTT who did not present with obstructive jaundice in terms of the overall survival rate (p = 0.5469). The perioperative outcomes for the HCC patients with BDTT did not depend on the presence or absence of preoperative jaundice. No patients in either BDTT group demonstrated 90-day mortality in this study. Conclusions: Hepatectomy should be considered for HCC patients with BDTT, even for patients with obstructive jaundice, because the surgical outcomes equivalent to those for HCC without BDTT can be achieved. |
Rights: | The original publication is available at www.springerlink.com |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/66904 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 折茂 達也
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