| Title: | Isolated gestational proteinuria preceding the diagnosis of preeclampsia : an observational study |
| Authors: | Yamada, Takahiro Browse this author →KAKEN DB |
| Obata-Yasuoka, Mana Browse this author →KAKEN DB |
| Hamada, Hiromi Browse this author →KAKEN DB |
| Baba, Yosuke Browse this author |
| Ohkuchi, Akihide Browse this author →KAKEN DB |
| Yasuda, Shun Browse this author |
| Kawabata, Kosuke Browse this author |
| Minakawa, Shiori Browse this author |
| Hirai, Chihiro Browse this author |
| Kusaka, Hideto Browse this author →KAKEN DB |
| Murabayashi, Nao Browse this author →KAKEN DB |
| Inde, Yusuke Browse this author |
| Nagura, Michikazu Browse this author |
| Umazume, Takeshi Browse this author →KAKEN DB |
| Itakura, Atsuo Browse this author →KAKEN DB |
| Maeda, Makoto Browse this author |
| Sagawa, Norimasa Browse this author →KAKEN DB |
| Ohno, Yasumasa Browse this author |
| Kataoka, Soromon Browse this author →KAKEN DB |
| Fujimori, Keiya Browse this author →KAKEN DB |
| Kudo, Yoshiki Browse this author →KAKEN DB |
| Ikeda, Tomoaki Browse this author →KAKEN DB |
| Nakai, Akihito Browse this author →KAKEN DB |
| Minakami, Hisanori Browse this author →KAKEN DB |
| Keywords: | Disease pregnancy |
| preeclampsia |
| pregnancy outcome |
| protein to creatinine ratio |
| proteinuria pregnancy |
| Issue Date: | Sep-2016 |
| Publisher: | Wiley |
| Journal Title: | Acta obstetricia et gynecologica Scandinavica |
| Volume: | 95 |
| Issue: | 9 |
| Start Page: | 1048 |
| End Page: | 1054 |
| Publisher DOI: | 10.1111/aogs.12915 |
| PMID: | 27109750 |
| Abstract: | Introduction. Some pregnant women develop significant proteinuria in the absence of hypertension. However, clinical significance of isolated gestational proteinuria (IGP) is not well understood. This study aimed to determine the prevalence of IGP in singleton pregnancies and the proportion of women with IGP who subsequently developed preeclampsia (IGP-PE) among all PE cases. Material and methods. This was an observational study of 6819 women with singleton pregnancies at 12 centers, including 938 women with at least once determination of protein-to-creatinine ratio (P/Cr). Significant proteinuria in pregnancy (SPIP) was defined as P/Cr (mg/mg) level >0.27. IGP was defined as SPIP in the absence of hypertension. Gestational hypertension (GH) preceding preeclampsia (GH-PE) was defined as preeclampsia (PE) in which GH preceded SPIP. Simultaneous PE (S-PE) was defined as PE in which both SPIP and hypertension occurred simultaneously. Results. IGP and PE were diagnosed in 130 (1.9%) and 158 (2.3%) of 6819 women, respectively. Of 130 women with IGP, 32 (25%) progressed to PE and accounted for 20% of all women with PE. Hence, women with IGP had a relative risk of 13.1 (95% CI; 9.2-18.5) for developing PE compared with those without IGP [25% (32/130) vs. 1.9% (126/6689)]. At diagnosis of SPIP, P/Cr levels already exceeded 1.0 more often in women with S-PE than in those with IGP-PE [67% (33/49) vs. 44% (14/32), respectively, p = 0.031]. Conclusions. IGP is a risk factor for PE, and IGP-PE accounts for a considerable proportion (20%) of all PE. |
| Rights: | This is the peer reviewed version of the following article: Yamada T, Obata-Yasuoka M, Hamada H, Baba Y, Ohkuchi A, Yasuda S, et al. Isolated gestational proteinuria preceding the diagnosis of preeclampsia – an observational study. Acta Obstet Gynecol Scand 2016; 95: 1048–1054, which has been published in final form at http://dx.doi.org/10.1111/aogs.12915. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/67076 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
