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Isolated gestational proteinuria preceding the diagnosis of preeclampsia : an observational study

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タイトル: Isolated gestational proteinuria preceding the diagnosis of preeclampsia : an observational study
著者: Yamada, Takahiro 著作を一覧する
Obata-Yasuoka, Mana 著作を一覧する
Hamada, Hiromi 著作を一覧する
Baba, Yosuke 著作を一覧する
Ohkuchi, Akihide 著作を一覧する
Yasuda, Shun 著作を一覧する
Kawabata, Kosuke 著作を一覧する
Minakawa, Shiori 著作を一覧する
Hirai, Chihiro 著作を一覧する
Kusaka, Hideto 著作を一覧する
Murabayashi, Nao 著作を一覧する
Inde, Yusuke 著作を一覧する
Nagura, Michikazu 著作を一覧する
Umazume, Takeshi 著作を一覧する
Itakura, Atsuo 著作を一覧する
Maeda, Makoto 著作を一覧する
Sagawa, Norimasa 著作を一覧する
Ohno, Yasumasa 著作を一覧する
Kataoka, Soromon 著作を一覧する
Fujimori, Keiya 著作を一覧する
Kudo, Yoshiki 著作を一覧する
Ikeda, Tomoaki 著作を一覧する
Nakai, Akihito 著作を一覧する
Minakami, Hisanori 著作を一覧する
キーワード: Disease pregnancy
preeclampsia
pregnancy outcome
protein to creatinine ratio
proteinuria pregnancy
発行日: 2016年 9月
出版者: Wiley
誌名: Acta obstetricia et gynecologica Scandinavica
巻: 95
号: 9
開始ページ: 1048
終了ページ: 1054
出版社 DOI: 10.1111/aogs.12915
抄録: Introduction. Some pregnant women develop significant proteinuria in the absence of hypertension. However, clinical significance of isolated gestational proteinuria (IGP) is not well understood. This study aimed to determine the prevalence of IGP in singleton pregnancies and the proportion of women with IGP who subsequently developed preeclampsia (IGP-PE) among all PE cases. Material and methods. This was an observational study of 6819 women with singleton pregnancies at 12 centers, including 938 women with at least once determination of protein-to-creatinine ratio (P/Cr). Significant proteinuria in pregnancy (SPIP) was defined as P/Cr (mg/mg) level >0.27. IGP was defined as SPIP in the absence of hypertension. Gestational hypertension (GH) preceding preeclampsia (GH-PE) was defined as preeclampsia (PE) in which GH preceded SPIP. Simultaneous PE (S-PE) was defined as PE in which both SPIP and hypertension occurred simultaneously. Results. IGP and PE were diagnosed in 130 (1.9%) and 158 (2.3%) of 6819 women, respectively. Of 130 women with IGP, 32 (25%) progressed to PE and accounted for 20% of all women with PE. Hence, women with IGP had a relative risk of 13.1 (95% CI; 9.2-18.5) for developing PE compared with those without IGP [25% (32/130) vs. 1.9% (126/6689)]. At diagnosis of SPIP, P/Cr levels already exceeded 1.0 more often in women with S-PE than in those with IGP-PE [67% (33/49) vs. 44% (14/32), respectively, p = 0.031]. Conclusions. IGP is a risk factor for PE, and IGP-PE accounts for a considerable proportion (20%) of all PE.
Rights: This is the peer reviewed version of the following article: Yamada T, Obata-Yasuoka M, Hamada H, Baba Y, Ohkuchi A, Yasuda S, et al. Isolated gestational proteinuria preceding the diagnosis of preeclampsia – an observational study. Acta Obstet Gynecol Scand 2016; 95: 1048–1054, which has been published in final form at http://dx.doi.org/10.1111/aogs.12915. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/67076
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 山田 崇弘

 

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