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Isolated gestational proteinuria preceding the diagnosis of preeclampsia : an observational study

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/67076

Title: Isolated gestational proteinuria preceding the diagnosis of preeclampsia : an observational study
Authors: Yamada, Takahiro Browse this author →KAKEN DB
Obata-Yasuoka, Mana Browse this author →KAKEN DB
Hamada, Hiromi Browse this author →KAKEN DB
Baba, Yosuke Browse this author
Ohkuchi, Akihide Browse this author →KAKEN DB
Yasuda, Shun Browse this author
Kawabata, Kosuke Browse this author
Minakawa, Shiori Browse this author
Hirai, Chihiro Browse this author
Kusaka, Hideto Browse this author →KAKEN DB
Murabayashi, Nao Browse this author →KAKEN DB
Inde, Yusuke Browse this author
Nagura, Michikazu Browse this author
Umazume, Takeshi Browse this author →KAKEN DB
Itakura, Atsuo Browse this author →KAKEN DB
Maeda, Makoto Browse this author
Sagawa, Norimasa Browse this author →KAKEN DB
Ohno, Yasumasa Browse this author
Kataoka, Soromon Browse this author →KAKEN DB
Fujimori, Keiya Browse this author →KAKEN DB
Kudo, Yoshiki Browse this author →KAKEN DB
Ikeda, Tomoaki Browse this author →KAKEN DB
Nakai, Akihito Browse this author →KAKEN DB
Minakami, Hisanori Browse this author →KAKEN DB
Keywords: Disease pregnancy
preeclampsia
pregnancy outcome
protein to creatinine ratio
proteinuria pregnancy
Issue Date: Sep-2016
Publisher: Wiley
Journal Title: Acta obstetricia et gynecologica Scandinavica
Volume: 95
Issue: 9
Start Page: 1048
End Page: 1054
Publisher DOI: 10.1111/aogs.12915
PMID: 27109750
Abstract: Introduction. Some pregnant women develop significant proteinuria in the absence of hypertension. However, clinical significance of isolated gestational proteinuria (IGP) is not well understood. This study aimed to determine the prevalence of IGP in singleton pregnancies and the proportion of women with IGP who subsequently developed preeclampsia (IGP-PE) among all PE cases. Material and methods. This was an observational study of 6819 women with singleton pregnancies at 12 centers, including 938 women with at least once determination of protein-to-creatinine ratio (P/Cr). Significant proteinuria in pregnancy (SPIP) was defined as P/Cr (mg/mg) level >0.27. IGP was defined as SPIP in the absence of hypertension. Gestational hypertension (GH) preceding preeclampsia (GH-PE) was defined as preeclampsia (PE) in which GH preceded SPIP. Simultaneous PE (S-PE) was defined as PE in which both SPIP and hypertension occurred simultaneously. Results. IGP and PE were diagnosed in 130 (1.9%) and 158 (2.3%) of 6819 women, respectively. Of 130 women with IGP, 32 (25%) progressed to PE and accounted for 20% of all women with PE. Hence, women with IGP had a relative risk of 13.1 (95% CI; 9.2-18.5) for developing PE compared with those without IGP [25% (32/130) vs. 1.9% (126/6689)]. At diagnosis of SPIP, P/Cr levels already exceeded 1.0 more often in women with S-PE than in those with IGP-PE [67% (33/49) vs. 44% (14/32), respectively, p = 0.031]. Conclusions. IGP is a risk factor for PE, and IGP-PE accounts for a considerable proportion (20%) of all PE.
Rights: This is the peer reviewed version of the following article: Yamada T, Obata-Yasuoka M, Hamada H, Baba Y, Ohkuchi A, Yasuda S, et al. Isolated gestational proteinuria preceding the diagnosis of preeclampsia – an observational study. Acta Obstet Gynecol Scand 2016; 95: 1048–1054, which has been published in final form at http://dx.doi.org/10.1111/aogs.12915. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
URI: http://hdl.handle.net/2115/67076
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山田 崇弘

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