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Synthesis and α-amylase inhibitory activity of glucose–deoxynojirimycin conjugates

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Title: Synthesis and α-amylase inhibitory activity of glucose–deoxynojirimycin conjugates
Authors: Kato, Eisuke Browse this author →KAKEN DB
Iwano, Naoya Browse this author
Yamada, Akihiko Browse this author
Kawabata, Jun Browse this author →KAKEN DB
Keywords: α-Amylase inhibitor
Glucosidase inhibitor
Diabetes mellitus
Issue Date: 7-Oct-2011
Publisher: Elsevier
Journal Title: Tetrahedron
Volume: 67
Issue: 40
Start Page: 7692
End Page: 7702
Publisher DOI: 10.1016/j.tet.2011.08.012
Abstract: Inhibitors of α-amylase have attracted attention for their putative effects against diabetes mellitus. Although numerous studies have explored natural small molecule inhibitors, acarbose is currently the only compound with sufficient inhibitory potency and drug-like characteristics to be considered as a potential therapeutic agent. We have synthesized conjugates of the potent glucosidase inhibitor, 1-deoxynojirimycin, and glucose, with the aim of enhancing inhibitory activity against α-amylase. This synthetic conjugate showed increased inhibition of α-amylase compared to 1-deoxynojirimycin alone, suggesting that similar modifications of existing glucosidase inhibitors may yield more potent α-amylase inhibitors.
Rights: © 2011, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 英介

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