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Early clinical experience utilizing scintillator with optical fiber (SOF) detector in clinical boron neutron capture therapy: its issues and solutions

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/68301

Title: Early clinical experience utilizing scintillator with optical fiber (SOF) detector in clinical boron neutron capture therapy: its issues and solutions
Authors: Ishikawa, Masayori Browse this author →KAKEN DB
Yamamoto, Tetsuya Browse this author
Matsumura, Akira Browse this author
Hiratsuka, Junichi Browse this author
Miyatake, Shin-Ichi Browse this author
Kato, Itsuro Browse this author
Sakurai, Yoshinori Browse this author
Kumada, Hiroaki Browse this author
Shrestha, Shubhechha J Browse this author
Ono, Koji Browse this author
Keywords: SOF detector
Ultra-miniature detector
Thermal neutron monitor
Clinical trial BNCT
Issue Date: Dec-2016
Publisher: BioMed Central
Journal Title: Radiation Oncology
Volume: 11
Issue: 1
Publisher DOI: 10.1186/s13014-016-0680-0
PMID: 27506665
Abstract: Background: Real-time measurement of thermal neutrons in the tumor region is essential for proper evaluation of the absorbed dose in boron neutron capture therapy (BNCT) treatment. The gold wire activation method has been routinely used to measure the neutron flux distribution in BNCT irradiation, but a real-time measurement using gold wire is not possible. To overcome this issue, the scintillator with optical fiber (SOF) detector has been developed. The purpose of this study is to demonstrate the feasibility of the SOF detector as a real-time thermal neutron monitor in clinical BNCT treatment and also to report issues in the use of SOF detectors in clinical practice and their solutions. Material and methods: Clinical measurements using the SOF detector were carried out in 16 BNCT clinical trial patients from December 2002 until end of 2006 at the Japanese Atomic Energy Agency (JAEA) and Kyoto University Research Reactor Institute (KURRI). Results: The SOF detector worked effectively as a real-time thermal neutron monitor. The neutron fluence obtained by the gold wire activation method was found to differ from that obtained by the SOF detector. The neutron fluence obtained by the SOF detector was in better agreement with the expected fluence than with gold wire activation. The estimation error for the SOF detector was small in comparison to the gold wire measurement. In addition, real-time monitoring suggested that the neutron flux distribution and intensity at the region of interest (ROI) may vary due to the reactor condition, patient motion and dislocation of the SOF detector. Conclusion: Clinical measurements using the SOF detector to measure thermal neutron flux during BNCT confirmed that SOF detectors are effective as a real-time thermal neutron monitor. To minimize the estimation error due to the displacement of the SOF probe during treatment, a loop-type SOF probe was developed.
Rights: http://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/68301
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石川 正純

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