HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
保健科学院・保健科学研究院  >
雑誌発表論文等  >

Early clinical experience utilizing scintillator with optical fiber (SOF) detector in clinical boron neutron capture therapy: its issues and solutions

この資料はクリエイティブ・コモンズ・ライセンスの下で公開されています。

フルテキスト
Radiation Oncology 11(1).pdf2.16 MBPDF見る/開く
この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/68301

タイトル: Early clinical experience utilizing scintillator with optical fiber (SOF) detector in clinical boron neutron capture therapy: its issues and solutions
著者: Ishikawa, Masayori 著作を一覧する
Yamamoto, Tetsuya 著作を一覧する
Matsumura, Akira 著作を一覧する
Hiratsuka, Junichi 著作を一覧する
Miyatake, Shin-Ichi 著作を一覧する
Kato, Itsuro 著作を一覧する
Sakurai, Yoshinori 著作を一覧する
Kumada, Hiroaki 著作を一覧する
Shrestha, Shubhechha J 著作を一覧する
Ono, Koji 著作を一覧する
キーワード: SOF detector
Ultra-miniature detector
Thermal neutron monitor
Clinical trial BNCT
発行日: 2016年12月
出版者: BioMed Central
誌名: Radiation Oncology
巻: 11
号: 1
出版社 DOI: 10.1186/s13014-016-0680-0
抄録: Background: Real-time measurement of thermal neutrons in the tumor region is essential for proper evaluation of the absorbed dose in boron neutron capture therapy (BNCT) treatment. The gold wire activation method has been routinely used to measure the neutron flux distribution in BNCT irradiation, but a real-time measurement using gold wire is not possible. To overcome this issue, the scintillator with optical fiber (SOF) detector has been developed. The purpose of this study is to demonstrate the feasibility of the SOF detector as a real-time thermal neutron monitor in clinical BNCT treatment and also to report issues in the use of SOF detectors in clinical practice and their solutions. Material and methods: Clinical measurements using the SOF detector were carried out in 16 BNCT clinical trial patients from December 2002 until end of 2006 at the Japanese Atomic Energy Agency (JAEA) and Kyoto University Research Reactor Institute (KURRI). Results: The SOF detector worked effectively as a real-time thermal neutron monitor. The neutron fluence obtained by the gold wire activation method was found to differ from that obtained by the SOF detector. The neutron fluence obtained by the SOF detector was in better agreement with the expected fluence than with gold wire activation. The estimation error for the SOF detector was small in comparison to the gold wire measurement. In addition, real-time monitoring suggested that the neutron flux distribution and intensity at the region of interest (ROI) may vary due to the reactor condition, patient motion and dislocation of the SOF detector. Conclusion: Clinical measurements using the SOF detector to measure thermal neutron flux during BNCT confirmed that SOF detectors are effective as a real-time thermal neutron monitor. To minimize the estimation error due to the displacement of the SOF probe during treatment, a loop-type SOF probe was developed.
資料タイプ: article
URI: http://hdl.handle.net/2115/68301
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 石川 正純

 

本サイトに関するご意見・お問い合わせは repo at lib.hokudai.ac.jp へお願いします。 - 北海道大学