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Difference in Antibody Responses to Mycobacterium tuberculosis Antigens in Japanese Tuberculosis Patients Infected with the Beijing/Non-Beijing Genotype

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Title: Difference in Antibody Responses to Mycobacterium tuberculosis Antigens in Japanese Tuberculosis Patients Infected with the Beijing/Non-Beijing Genotype
Authors: Zhao, Jingge Browse this author
Shiratori, Beata Browse this author
Okumura, Masao Browse this author
Yanai, Hideki Browse this author
Matsumoto, Makoto Browse this author
Nakajima, Chie Browse this author →KAKEN DB
Mizuno, Kazue Browse this author
Ono, Kenji Browse this author
Oda, Tetsuya Browse this author
Chagan-Yasutan, Haorile Browse this author
Ashino, Yugo Browse this author
Matsuba, Takashi Browse this author
Yoshiyama, Takashi Browse this author
Suzuki, Yasuhiko Browse this author →KAKEN DB
Hattori, Toshio Browse this author
Issue Date: 15-Jan-2017
Publisher: Hindawi Publishing Corporation
Journal Title: Journal of Immunology Research
Volume: 2017
Start Page: 4797856
Publisher DOI: 10.1155/2017/4797856
Abstract: The Beijing genotype Mycobacterium tuberculosis (MTB), notorious for its virulence and predisposition to relapse, could be identified by spoligotyping based on genetic heterogeneity. The plasma samples from 20 cases of Beijing and 16 cases of non- Beijing MTB infected individuals and 24 healthy controls (HCs) were collected, and antibodies against 11 antigens (Rv0679c142Asn, Rv0679c142Lys,Ag85B,Ag85A, ARC,TDM-M,TDM-K,HBHA,MDP-1, LAM, and TBGL)were measured by ELISA. Compared to theHCs, the MTB infected subjects showed higher titers of anti-Ag85B IgG (positivity 58.2%) and anti-ACR IgG (positivity 48.2%). Of note, anti-ACR IgG showed higher titer in Beijing MTB infected tuberculosis (TB) patients than in HC (Kruskal-Wallis test, P < 0.05), while the levels of anti-Ag85B, anti-TBGL, anti-TDM-K, and anti-TDM-M IgG were higher in non-Beijing TB patients than in HC. Moreover, anti-Ag85B IgG showed higher response in non-Beijing TB patients than in Beijing TB patients (P < 0.05; sensitivity, 76.9% versus 44.4%).The sensitivity and specificity analysis showed that 78.8% Beijing infected individualswere negative in anti-TBGL-IgG or/and anti-Ag85B-IgG, while 75.0% of those were positive in anti-TBGL-IgA or/and anti-ACR-IgG tests. These results indicate the possibility of developing antibody-based test to identify Beijing MTB.
Rights: http://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/68487
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 鈴木 定彦

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