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Relationships of left ventricular strain and strain rate to wall stress and their afterload dependency

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Title: Relationships of left ventricular strain and strain rate to wall stress and their afterload dependency
Other Titles: Relations of Strain Parameters to Wall Stress
Authors: Murai, Daisuke Browse this author
Yamada, Satoshi Browse this author →KAKEN DB
Hayashi, Taichi Browse this author
Okada, Kazunori Browse this author
Nishino, Hisao Browse this author
Nakabachi, Masahiro Browse this author
Yokoyama, Shinobu Browse this author
Abe, Ayumu Browse this author
Ichikawa, Ayako Browse this author
Ono, Kota Browse this author
Kaga, Sanae Browse this author
Iwano, Hiroyuki Browse this author →KAKEN DB
Mikami, Taisei Browse this author →KAKEN DB
Tsutsui, Hiroyuki Browse this author →KAKEN DB
Keywords: Strain
Strain rate
Speckle tracking echocardiography
Wall stress
Issue Date: May-2017
Publisher: Springer
Journal Title: Heart and vessels
Volume: 32
Issue: 5
Start Page: 574
End Page: 583
Publisher DOI: 10.1007/s00380-016-0900-4
PMID: 27734145
Abstract: Whether and how left ventricular (LV) strain and strain rate correlate with wall stress is not known. Furthermore, it is not determined whether strain or strain rate is less dependent on the afterload. In 41 healthy young adults, LV global peak strain and systolic peak strain rate in the longitudinal direction (LS and LSR, respectively) and circumferential direction (CS and CSR, respectively) were measured layer-specifically using speckle tracking echocardiography (STE) before and during a handgrip exercise. Among all the points before and during the exercise, all the STE parameters significantly correlated linearly with wall stress (LS: r = -0.53, p < 0.01, LSR: r = -0.28, p < 0.05, CS in the inner layer: r = -0.72, p < 0.01, CSR in the inner layer: r = -0.47, p < 0.01). Strain more strongly correlated with wall stress than strain rate (r = -0.53 for LS vs. r = -0.28 for LSR, p < 0.05; r = -0.72 for CS vs. r = -0.47 for CSR in the inner layer, p < 0.05), whereas the interobserver variability was similar between strain and strain rate (longitudinal 6.2 vs. 5.2 %, inner circumferential 4.8 vs. 4.7 %, mid-circumferential 7.9 vs. 6.9 %, outer circumferential 10.4 vs. 9.7 %), indicating that the differences in correlation coefficients reflect those in afterload dependency. It was thus concluded that LV strain and strain rate linearly and inversely correlated with wall stress in the longitudinal and circumferential directions, and strain more strongly depended on afterload than did strain rate. Myocardial shortening should be evaluated based on the relationships between these parameters and wall stress.
Rights: The final publication is available at
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山田 聡

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