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Effect of combined treatment with bisphosphonate and vitamin D on atherosclerosis in patients with systemic lupus erythematosus : a propensity score-based analysis

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Title: Effect of combined treatment with bisphosphonate and vitamin D on atherosclerosis in patients with systemic lupus erythematosus : a propensity score-based analysis
Authors: Ohmura, Kazumasa Browse this author
Kato, Masaru Browse this author →KAKEN DB
Watanabe, Toshiyuki Browse this author
Oku, Kenji Browse this author
Bohgaki, Toshiyuki Browse this author
Horita, Tetsuya Browse this author →KAKEN DB
Yasuda, Shinsuke Browse this author →KAKEN DB
Ito, Yoichi M. Browse this author →KAKEN DB
Sato, Norihiro Browse this author
Atsumi, Tatsuya Browse this author →KAKEN DB
Keywords: Systemic lupus erythematosus
Atherosclerosis
Osteoporosis
Bisphosphonates
Vitamin D
Issue Date: 17-Apr-2018
Publisher: BioMed Central
Journal Title: Arthritis research & therapy
Volume: 20
Start Page: 72
Publisher DOI: 10.1186/s13075-018-1589-9
Abstract: Background: Premature atherosclerosis is one of the major complications of systemic lupus erythematosus (SLE). Recently, the biological linkage between atherosclerosis and osteoporosis has garnered much attention. The aim of this study is to explore correlation between the development of atherosclerosis and anti-osteoporotic treatment. Methods: Consecutive patients with SLE (n = 117) who underwent carotid ultrasonography were retrospectively analyzed using propensity scoring. Results: Of the 117 patients, 42 (36%), 27 (23%), and 30 (26%) were receiving bisphosphonates and vitamin D (BP + VD), bisphosphonates alone, or vitamin D alone, respectively. Low bone mineral density was more frequent, and carotid plaque was less prevalent in the BP + VD group compared with other treatment groups. Age (OR = 1.57) and BP + VD treatment (OR = 0.24) were shown by multivariate analysis to be associated with the presence of carotid plaque. In all strata divided using the propensity score, carotid plaque was statistically significantly less prevalent (p = 0.015, Mantel-Haenszel test) in the BP + VD group relative to the other treatment groups. Conclusion: Combined treatment with bisphosphonate and vitamin D may have a role in preventing atherosclerosis in patients with SLE.
Rights: http://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/70976
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 将

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