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Dietary alpha-cyclodextrin reduces atherosclerosis and modifies gut flora in apolipoprotein E-deficient mice

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Title: Dietary alpha-cyclodextrin reduces atherosclerosis and modifies gut flora in apolipoprotein E-deficient mice
Authors: Sakurai, Toshihiro Browse this author
Sakurai, Akiko Browse this author
Chen, Ye Browse this author
Vaisman, Boris L. Browse this author
Amar, Marcelo J. Browse this author
Pryor, Milton Browse this author
Thacker, Seth G. Browse this author
Zhang, Xue Browse this author
Wang, Xujing Browse this author
Zhang, Yubo Browse this author
Zhu, Jun Browse this author
Yang, Zhi-Hong Browse this author
Freeman, Lita A. Browse this author
Remaley, Alan T. Browse this author
Keywords: Atherosclerosis
Dietary fiber
Gut flora
Issue Date: 16-Aug-2017
Publisher: John Wiley & Sons
Journal Title: Molecular nutrition & food research
Volume: 61
Issue: 8
Start Page: 1600804
Publisher DOI: 10.1002/mnfr.201600804
PMID: 28102587
Abstract: Scope: alpha-Cyclodextrin (alpha-CD), a cyclic polymer of glucose, has been shown to lower plasma cholesterol in animals and humans; however, its effect on atherosclerosis has not been previously described. Methods and results: apoE-knockout mice were fed either low-fat diet (LFD; 5.2% fat, w/w), or Western high fat diet (21.2% fat) containing either no additions (WD), 1.5% alpha-CD (WDA); 1.5% beta-CD (WDB); or 1.5% oligofructose-enriched inulin (WDI). Although plasma lipids were similar after 11 weeks on theWDvs. WDA diets, aortic atherosclerotic lesions were 65% less in mice on WDA compared toWD (P < 0.05), and similar tomice fed the LFD. No effect on atherosclerosis was observed for the other WD supplemented diets. By RNA-seq analysis of 16S rRNA, addition of alpha-CD to the WD resulted in significantly decreased cecal bacterial counts in genera Clostridium and Turicibacterium, and significantly increased Dehalobacteriaceae. At family level, Comamonadaceae significantly increased and Peptostreptococcaceae showed a negative trend. Several of these bacterial count changes correlated negatively with % atherosclerotic lesion and were associated with increased cecum weight and decreased plasma cholesterol levels. Conclusion: Addition of alpha-CD to the diet of apoE-knockoutmice decreases atherosclerosis and is associated with changes in the gut flora.
Rights: This is the peer reviewed version of the following article: Toshihiro Sakurai, Akiko Sakurai, Ye Chen, Boris L. Vaisman, Marcelo J. Amar, Milton Pryor, Seth G. Thacker, Xue Zhang, Xujing Wang, Yubo Zhang, Jun Zhu, Zhi-Hong Yang, Lita A. Freeman, Alan T. Remaley (2017), Dietary alpha-cyclodextrin reduces atherosclerosis and modifies gut flora in apolipoprotein E-deficient mice. Molecular nutrition & food research, 61(8): 1600804., which has been published in final form at 10.1002/mnfr.201600804. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 櫻井 俊宏

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