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Heterogeneous genetic make-up of Japanese house mice (Mus musculus) created by multiple independent introductions and spatio-temporally diverse hybridization processes

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Title: Heterogeneous genetic make-up of Japanese house mice (Mus musculus) created by multiple independent introductions and spatio-temporally diverse hybridization processes
Authors: Kuwayama, Takashi Browse this author
Nunome, Mitsuo Browse this author →KAKEN DB
Kinoshita, Gohta Browse this author
Abe, Kuniya Browse this author
Suzuki, Hitoshi Browse this author →KAKEN DB
Keywords: Mus musculus
nuclear gene haplotype
peopling of Japan
recombination
secondary contact
Issue Date: Nov-2017
Publisher: Oxford University Press
Journal Title: Biological journal of the Linnean Society
Volume: 122
Issue: 3
Start Page: 661
End Page: 674
Publisher DOI: 10.1093/biolinnean/blx076
Abstract: In this study, phylogenetic analysis of relatively long sequences of mitochondrial DNA (4225 bp) in the Japanese house mouse Mus musculus provides the first evidence that both southern Asian subspecies of Mus musculus castaneus (CAS) and northern Asian subspecies of Mus musculus musculus (MUS) arrived in Japan through rapid population expansion events, from Southern China similar to 4000 years ago and the Korean Peninsula similar to 2000 years ago, respectively. Nuclear DNA haplotype structure analyses targeting a chromosome region with two different tract sizes, 1 and 5 Mb, consisting of nine and six tandemly arranged markers, respectively, yielded a possible average fragment length of 170 kb of CAS haplotypes in the MUS background genome in northern Japan, providing a rough estimate of its elapsed time of 815 generations under an assumption of continued backcrossing. Less frequent and shortened CAS-like haplotypes specific to Japan were detected, suggesting ancient introduction prior to the appearance of the South Chinese CAS in Japan. Our analyses also showed sporadic appearance of long fragments (2-5 Mb) from the west European subspecies Mus musculus domesticus, indicating contemporary stowaway introduction. Overall, multiple overseas introductions, and the time-lagged inter-subspecies genetic admixture, probably resulted in the heterogeneous state of Japanese wild mice.
Rights: This is a pre-copyedited, author-produced version of an article accepted for publication in Biological Journal of the Linnean Society following peer review. The version of record Biological Journal of the Linnean Society, Volume 122, Issue 3, 25 October 2017, Pages 661–674 is available online at: https://doi.org/10.1093/biolinnean/blx076.
Type: article (author version)
URI: http://hdl.handle.net/2115/71740
Appears in Collections:環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 鈴木 仁

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