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Pregnancy specific regulation of lysosomal cathepsins in bovine blood leukocytes [an abstract of entire text]
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| Title: | Pregnancy specific regulation of lysosomal cathepsins in bovine blood leukocytes [an abstract of entire text] |
| Other Titles: | ウシ末梢白血球におけるリソソームカテプシンの妊娠特異的応答機構に関する研究 [全文の要約] |
| Authors: | Talukder, Md. Abdus Shabur Browse this author |
| Issue Date: | 25-Sep-2018 |
| Publisher: | Hokkaido University |
| Abstract: | In most mammalian species, an embryo secretes signals to specify its presence to the mother for successful establishment of pregnancy. The interferon tau (IFNT), a key pregnancy recognition signal in ruminants, is secreted from the trophectoderm of the conceptus at the blastocyst stage and its level increases with the elongation of the conceptus. The IFNT during the maternal recognition period (MRP) is important for successful establishment of pregnancy in ruminants. During the pregnancy recognition period, IFNT acts to uterine tissues to silence the expression of estrogen receptor (ESR) alpha and oxytocin receptor (OXTR), which prevents the oxytocin-dependent release of luteolytic pulses of prostaglandin F2α (PGF2α)secretion by uterine tissue. Therefore, the corpus luteum (CL) continues to produce progesterone required for maintenance of pregnancy. IFNT may act other organs and cells than that the uterine tissue. Recently, it has reported that pregnancy induced up-regulation of interferon stimulated gene 15 (ISG15) and myxovirus resistance 1 (MX1)genes in bovine liver on d18 and peripheral blood leukocytes (PBLs). Therefore, it is necessary to discovery other novel markers which have the ability to detect pregnancy at earlier period with easy and clear manner. Recently, it has been reported that lysosomal cysteine proteases are activated by type 1 IFN (IFN-β) in in vitro culture of mouse macrophages. Type 1 IFN stimulated pathway may be involved in several types of cell like blood leukocytes because type 1 IFN pathway exists in many types of somatic cells. The ISGs may be activated in lysosomal CTSs through type 1 IFN cell signaling pathway in PBLs and possibly to play important roles during early pregnancy in ruminants. Inter estingly, up-regulation of ISGs expression has been identified in circulating immune cells during implantation, making these factors a potential source of non-invasive biomarkers for early pregnancy. Therefore, this study was conducted to explore the dynamics of lysosomes and lysosomal CTSs in PBLs collected from pregnant and non-pregnant dairy cows, and conducted in vitro IFNT-stimulation of blood leukocytes from cyclic cows. |
| Description: | この博士論文全文の閲覧方法については、以下のサイトをご参照ください。 |
| Description URI: | https://www.lib.hokudai.ac.jp/dissertations/copy-guides/ |
| Conffering University: | 北海道大学 |
| Degree Report Number: | 甲第13322号 |
| Degree Level: | 博士 |
| Degree Discipline: | 農学 |
| Examination Committee Members: | (主査) 教授 高橋 昌志, 教授 小林 泰男, 准教授 川原 学, 助教 唄 花子 |
| Degree Affiliation: | 農学院（生物資源科学専攻） |
| Type: | theses (doctoral - abstract of entire text) |
| URI: | http://hdl.handle.net/2115/71861 |
| Appears in Collections: | 学位論文 (Theses) > 博士 （農学）
課程博士 (Doctorate by way of Advanced Course) > 農学院(Graduate School of Agriculture)
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