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Serum adiponectin and insulin secretion : A direct or inverse association?
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| Title: | Serum adiponectin and insulin secretion : A direct or inverse association? |
| Authors: | Nakamura, Akinobu Browse this author →KAKEN DB | | Miyoshi, Hideaki Browse this author →KAKEN DB | | Ukawa, Shigekazu Browse this author →KAKEN DB | | Nakamura, Koshi Browse this author →KAKEN DB | | Nakagawa, Takafumi Browse this author | | Terauchi, Yasuo Browse this author | | Tamakoshi, Akiko Browse this author →KAKEN DB | | Atsumi, Tatsuya Browse this author →KAKEN DB |
| Keywords: | Adiponectin | | Disposition index | | Insulin secretion |
| Issue Date: | Sep-2018 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Journal of diabetes investigation |
| Volume: | 9 |
| Issue: | 5 |
| Start Page: | 1106 |
| End Page: | 1109 |
| Publisher DOI: | 10.1111/jdi.12821 |
| Abstract: | We investigated the association between serum high molecular weight (HMW) adiponectin and insulin secretion in a population-based study, with or without adjustment for insulin sensitivity. A total of 488 participants (263 women) were included in the present study. Insulin secretion was estimated using the homeostasis model assessment of β-cell function ± adjustment for insulin resistance using the disposition index. Multivariate analysis showed that HMW adiponectin was significantly and inversely associated with homeostasis model assessment of β-cell function (partial regression coefficient -0.19, 95% confidence interval -0.28, -0.10, P < 0.0001). However, HMW adiponectin was significantly and positively associated with disposition index (partial regression coefficient 0.15, 95% confidence interval 0.06, 0.24, P = 0.0016). The present study showed that a positive association between HMW adiponectin levels and insulin secretion evaluated using an index incorporating adjustment for insulin resistance was identified, and vice versa using an index that did not adjust for insulin resistance. |
| Rights: | http://creativecommons.org/licenses/by-nc/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/71862 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 中村 昭伸
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