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Serum adiponectin and insulin secretion : A direct or inverse association?

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Title: Serum adiponectin and insulin secretion : A direct or inverse association?
Authors: Nakamura, Akinobu Browse this author →KAKEN DB
Miyoshi, Hideaki Browse this author →KAKEN DB
Ukawa, Shigekazu Browse this author →KAKEN DB
Nakamura, Koshi Browse this author →KAKEN DB
Nakagawa, Takafumi Browse this author
Terauchi, Yasuo Browse this author
Tamakoshi, Akiko Browse this author →KAKEN DB
Atsumi, Tatsuya Browse this author →KAKEN DB
Keywords: Adiponectin
Disposition index
Insulin secretion
Issue Date: Sep-2018
Publisher: John Wiley & Sons
Journal Title: Journal of diabetes investigation
Volume: 9
Issue: 5
Start Page: 1106
End Page: 1109
Publisher DOI: 10.1111/jdi.12821
Abstract: We investigated the association between serum high molecular weight (HMW) adiponectin and insulin secretion in a population-based study, with or without adjustment for insulin sensitivity. A total of 488 participants (263 women) were included in the present study. Insulin secretion was estimated using the homeostasis model assessment of β-cell function ± adjustment for insulin resistance using the disposition index. Multivariate analysis showed that HMW adiponectin was significantly and inversely associated with homeostasis model assessment of β-cell function (partial regression coefficient -0.19, 95% confidence interval -0.28, -0.10, P < 0.0001). However, HMW adiponectin was significantly and positively associated with disposition index (partial regression coefficient 0.15, 95% confidence interval 0.06, 0.24, P = 0.0016). The present study showed that a positive association between HMW adiponectin levels and insulin secretion evaluated using an index incorporating adjustment for insulin resistance was identified, and vice versa using an index that did not adjust for insulin resistance.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 中村 昭伸

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