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STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization

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タイトル: STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization
著者: Kitai, Yuichi 著作を一覧する
Iwakami, Masashi 著作を一覧する
Saitoh, Kodai 著作を一覧する
Togi, Sumihito 著作を一覧する
Isayama, Serina 著作を一覧する
Sekine, Yuichi 著作を一覧する
Muromoto, Ryuta 著作を一覧する
Kashiwakura, Jun-ichi 著作を一覧する
Yoshimura, Akihiko 著作を一覧する
Oritani, Kenji 著作を一覧する
Matsuda, Tadashi 著作を一覧する
キーワード: adaptor protein
prostate cancer
protein degradation
signal transduction
STAT3
c-CBL
発行日: 2017年11月24日
出版者: American Society for Biochemistry and Molecular Biology (ASBMB)
誌名: Journal of Biological Chemistry (JBC)
巻: 292
号: 47
開始ページ: 19392
終了ページ: 19399
出版社 DOI: 10.1074/jbc.M117.802884
抄録: Signal-transducing adaptor family member-2 (STAP-2) is an adaptor protein that regulates various intracellular signaling pathways and promotes tumorigenesis in melanoma and breast cancer cells. However, the contribution of STAP-2 to the behavior of other types of cancer cells is unclear. Here, we show that STAP-2 promotes tumorigenesis of prostate cancer cells through up-regulation of EGF receptor (EGFR) signaling. Tumor growth of a prostate cancer cell line, DU145, was strongly decreased by STAP-2 knockdown. EGF-induced gene expression and phosphorylation of AKT, ERK, and STAT3 were significantly decreased in STAP-2-knockdown DU145 cells. Mechanistically, we found that STAP-2 interacted with EGFR and enhanced its stability by inhibiting c-CBL-mediated EGFR ubiquitination. Our results indicate that STAP-2 promotes prostate cancer progression via facilitating EGFR activation.
Rights: This research was originally published in J. Biol. Chem. Kitai,Yuichi et al. STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization. J. Biol. Chem. 2017; 292(47):19392-19399. © the American Society for Biochemistry and Molecular Biology.
資料タイプ: article
URI: http://hdl.handle.net/2115/72029
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 松田 正

 

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