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Volume 67 Number 1 >

Molecular Evolution of Porcine Reproductive and Respiratory Syndrome Virus in Guangxi of China from 2012 to 2015

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Title: Molecular Evolution of Porcine Reproductive and Respiratory Syndrome Virus in Guangxi of China from 2012 to 2015
Authors: Song, Mingyue Browse this author
Zhang, Qiaoya Browse this author
Shan, Hu Browse this author
Yu, Binhui Browse this author
Xiong, Yi Browse this author
Li, Junwei Browse this author
Keywords: PRRSV
phylogenetic analysis
Issue Date: Feb-2019
Publisher: Faculty of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 67
Issue: 1
Start Page: 75
End Page: 81
Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important pathogens for swine industry, and caused significant economic losses worldwide. To better understand the genetic diversity of PRRSVs in Southwestern China, 63 PRRSV strains were isolated in Guangxi Province from 2012-2015. GP5 genes of these PRRSV isolates were sequenced and analyzed with those of representative PRRSVs. Phylogenetic analysis of GP5 genes shows 61 isolates of those are highly homologous with JXA1 and one isolate is variant of strain CH-1a. Furthermore, NADC30-like PRRSV strains were not isolated in our study. Subsequently, five antigenic epitopes of all GP5 protein were analyzed. Results showed amino acids with high frequency of mutation are L39I, V185A, I189L, T121I, F127L, R151K, I161V, Q196L, Q196R. Among these amino acids, T121I, F127L, R151K and I161V locate in T cell epitopes. And, our results suggest further investigation should be conducted to elucidate function of these mutation sites with high frequency.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 67 Number 1

Submitter: 獣医学部図書室

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