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Volume 67 Number 1 >

Anesthetic effect of a mixture of medetomidine, midazolam and butorphanol in chickens with antagonism by atipamezole

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.67.1.133

Title: Anesthetic effect of a mixture of medetomidine, midazolam and butorphanol in chickens with antagonism by atipamezole
Authors: Inoue, Atsuko Browse this author
Ochi, Takehiro Browse this author
Keywords: anesthetic combination
chicken
Issue Date: Feb-2019
Publisher: Faculty of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 67
Issue: 1
Start Page: 133
End Page: 137
Abstract: The anesthetic effect of a mixture of medetomidine, midazolam and butorphanol (Me/Mi/Bu), administered subcutaneously, was evaluated in healthy chickens. The Me/Mi/Bu mixture dose-dependently induced the duration of anesthesia. However, treatment with only one drug (Me 0.64 mg/kg, Mi 4.8 mg/kg or Bu 6.4 mg/kg) did not induce an anesthetic effect during the tests. The anesthetic effect of the Me/Mi/Bu mixture (Me/Mi/Bu: 0.64/4.8/6.4 mg/kg) was abolished by the α2-adrenoceptor antagonist atipamezole. No marked changes in the body weight were observed in the chicken administered with these drugs. Taken together, these results suggest that the Me/Mi/Bu mixture exhibits reversible anesthetic effect and is safe to be used in studies involving chickens.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/72753
Appears in Collections:Japanese Journal of Veterinary Research > Volume 67 Number 1

Submitter: 獣医学部図書室

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